Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma
Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma
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DOI：
10.1007/s00234-015-1591-8
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发表时间：
2016-01-01
期刊：
影响因子：
2.8
通讯作者：
Wang, Yongfei
中科院分区：
文献类型：
--
作者：
Ma, Zengyi;He, Wenqiang;Wang, Yongfei
人们普遍认为，垂体腺瘤(PA)的密度和血供会影响手术效果。本研究的目的是确定MRI信号强度(SI)是否与垂体大腺瘤的一致性或血供有关。对48例垂体大腺瘤患者进行了术前MRI检查，包括平扫和增强(CE)T1自旋回波(T1-SE)成像、不同翻转角度演变(SPACE)成像和灌注加权成像(PWI)应用优化对比度的CE采样完善。肿瘤的密度和血供由神经外科医生决定。免疫组织化学方法检测IV型胶原和MIB-1的表达。采用Kruskal-Wallis等级检验(K-W检验)分析肿瘤与正常额叶白质的相对SI值和PWI与肿瘤密度、血供、IV型胶原和MiB-1表达水平的相关性。在平扫T1-SE图像上，肿瘤的一致性与RSI显著相关(P=0.004)，而在CET1-SE和CE空间成像上则无相关性。在T1-SE像上，IV型胶原的表达与RSI显著相关(P=0.010)。血供与相对脑血流量呈正相关(P=0.030)。此外，MIB-1的表达与CET1-SE显像的RSI呈正相关(P=0.007)，提示T1-SE显像可能是预测PA稠度的一种简单而有用的方法。CBV值可为评估垂体大腺瘤的血供提供有价值的信息。
It is a common view that consistency and blood supply of pituitary adenoma (PA) can influence the surgical effect. The aim of this study was to determine whether MRI signal intensity (SI) was correlated to the consistency or blood supply of pituitary macroadenoma.Forty eight pituitary macroadenoma patients were underwent preoperative MRI, including precontrast and contrast-enhanced (CE) T1-spin echo (T1-SE) imaging, CE-sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) imaging, and perfusion-weighted imaging (PWI). The tumor consistency and blood supply were determined by neurosurgeons. The expression of collagen IV and MIB-1 was detected with immunohistology. The correlation of the relative SI (rSI) values (tumor to normal frontal white matter SI) and PWI data to the tumor consistency, blood supply, and the expression level of collagen IV and MIB-1 was statistically studied by Kruskal-Wallis rank test (K-W test).A significant correlation was observed between the tumor consistency and the rSI on precontrast T1-SE imaging (P = 0.004) but not on CE T1-SE and CE SPACE imaging. The expression of collagen IV was also significantly associated with rSI on T1-SE imaging (P = 0.010). The blood supply was correlated with the relative CBV (rCBV) (P = 0.030). In addition, the expression of MIB-1 was correlated with rSI of CE T1-SE imaging (P = 0.007).Our results suggest that T1-SE imaging may be a simple and useful method for predicting consistency of PA. CBV value can provide helpful information for assessing the blood supply of pituitary macroadenoma.