A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans
A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans
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DOI：
10.1016/j.neuroimage.2005.08.065
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发表时间：
2006-01-15
期刊：
影响因子：
5.7
通讯作者：
Boas, DA
中科院分区：
文献类型：
--
作者：
Huppert, TJ;Hoge, RD;Boas, DA
在这项研究中，我们在受试者的事件相关运动活动中进行了同步近红外光谱(NIRS)以及基于BOLD(血氧水平依赖)和ASL(动脉自旋标记)的功能磁共振成像，以比较在每种方法中记录的血流动力学响应的时间动力学。这些测量使我们能够检查每种模式下生物物理模型的有效性，因此，我们可以更深入地了解神经元激活时的血流动力学反应。虽然先前的研究已经通过类似的实验检验了这两种方法之间的关系，但由于各种原因，它们在文献中产生了相互矛盾的结果。在这里，通过采用短时间、事件相关的运动任务，我们能够强调血流动力学参数之间的细微时间差异，并具有高对比度噪声比。由于这种改进的实验设计，我们能够报告，fMRI测量的BOLD反应与脱氧血红蛋白的NIRS测量(R=0.98；P<；10(-20))比与脱氧血红蛋白(R=0.71)或总血红蛋白(R=0.53)的NIRS测量更相关。这一结果是从大胆反应的理论基础预测的，并与之前的几项工作一致[Toronov，V.A.W.，Choi，J.H.，Wolf，M.，Michalos，A.，Gratton，E.，Hueber，D.，2001。“同时使用近红外光谱和功能磁共振成像研究人脑血流动力学。”地中海医院。太棒了。28(4)521-527；麦金托什，B.J.，克拉森，L.M.，梅农，R.S.，2003。在成人同时进行的近红外光谱的两部分功能成像研究中，屏气挑战时的瞬时血流动力学。神经影像20 1246-1252；Toronov，V.A.W.，Walker，S.，Gupta，R.，Choi，J.H.，Gratton，E.，Hueber，D.，Webb，A.，2003。“脱氧血红蛋白浓度和局部脑血容量的变化在功能磁共振成像BOLD信号中的作用”，神经影像19(4)1521-1531]。这些数据还使我们能够检查更详细的fMRI信号测量模型，并评论血氧饱和度和血容量对大胆反应的作用。此外，我们还发现NIRS测得的总血红蛋白与ASL测得的脑血流量(R=0.91；P<；10(-10))和氧合血红蛋白与血流量(R=0.83；P<；10(-05))具有很高的相关性。最后，我们注意到血流动力学反应的幅度变化和到达峰值的时间存在显著的跨模式、相关性、受试者间的变异性。受试者之间观察到的这些参数的协方差符合血流动力学模型，并进一步支持了fMRI和NIRS具有相似的血管敏感性。(C)2005 Elsevier Inc.保留所有权利。
In this study, we have preformed simultaneous near-infrared spectroscopy (NIRS) along with BOLD (blood oxygen level dependent) and ASL (arterial spin labeling)-based fMRI during an event-related motor activity in human subjects in order to compare the temporal dynamics of the hemodynamic responses recorded in each method. These measurements have allowed us to examine the validity of the biophysical models underlying each modality and, as a result, gain greater insight into the hemodynamic responses to neuronal activation. Although prior studies have examined the relationships between these two methodologies through similar experiments, they have produced conflicting results in the literature for a variety of reasons. Here, by employing a short-duration, event-related motor task, we have been able to emphasize the subtle temporal differences between the hemodynamic parameters with a high contrast-to-noise ratio. As a result of this improved experimental design, we are able to report that the fMRI measured BOLD response is more correlated with the NIRS measure of deoxy-hemoglobin (R = 0.98; P < 10(-20)) than with deoxy-hemoglobin (R = 0.71), or total hemoglobin (R = 0.53). This result was predicted from the theoretical grounds of the BOLD response and is in agreement with several previous works [Toronov, V.A.W., Choi, J.H., Wolf, M., Michalos, A., Gratton, E., Hueber, D., 2001. "Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging." Med. Phys. 28 (4) 521-527; MacIntosh, B.J., Klassen, L.M., Menon, R.S., 2003. "Transient hemodynamics during a breath hold challenge in a two part functional imaging study with simultaneous near-infrared spectroscopy in adult humans." NeuroImage 20 1246-1252; Toronov, V.A.W., Walker, S., Gupta, R., Choi, J.H., Gratton, E., Hueber, D., Webb, A., 2003. "The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal" Neuroimage 19 (4) 1521-1531]. These data have also allowed us to examine more detailed measurement models of the fMRI signal and comment on the roles of the oxygen saturation and blood volume contributions to the BOLD response. In addition, we found high correlation between the NIRS measured total hemoglobin and ASL measured cerebral blood flow (R = 0.91; P < 10(-10)) and oxy-hemoglobin with flow (R = 0.83; P < 10(-05)) as predicted by the biophysical models. Finally, we note a significant amount of cross-modality, correlated, inter-subject variability in amplitude change and time-to-peak of the hemodynamic response. The observed co-variance in these parameters between subjects is in agreement with hemodynamic models and provides further support that fMRI and NIRS have similar vascular sensitivity. (c) 2005 Elsevier Inc. All rights reserved.