Cardiac resynchronization in chronic heart failure
Cardiac resynchronization in chronic heart failure
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DOI：
10.1056/nejmoa013168
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发表时间：
2002-06-13
影响因子：
158.5
通讯作者：
McAtee, P
中科院分区：
文献类型：
--
作者：
Abraham, WT;Fisher, WG;McAtee, P
背景资料：先前的研究表明，通过心房同步双心室起搏实现的心脏起搏在具有心室内传导延迟的心力衰竭患者中产生临床益处。我们进行了一项双盲试验来评估这种治疗方法。453例有中重度心力衰竭症状，射血分数小于等于35%，QRS间期大于等于130 msec的患者被随机分配到心脏起搏组228例患者或对照组（225例患者）6个月，同时维持心力衰竭的常规治疗。主要终点为纽约心脏协会功能分级、生活质量和6分钟步行距离。结果：与对照组相比，心脏起搏组患者6分钟步行距离（+39 vs +10 m，P=0.005）、功能分级（P
Background: Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach.Methods: Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes.Results: As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional class (P