One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results.
One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results.
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DOI：
10.1007/s12306-013-0242-7
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发表时间：
2013-08-01
影响因子：
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通讯作者：
Giannini, Sandro
中科院分区：
文献类型：
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作者：
Buda, Roberto;Vannini, Francesca;Giannini, Sandro
膝关节骨软骨炎病变（OLK）是膝关节疼痛和相关疾病的常见原因。一种新的骨髓间充质干细胞技术已被开发用于治疗OLK。30例OLK患者接受了关节镜下一步法手术。从患者的后髂嵴采集骨髓，并在关节镜下将支架植入病变部位。进行临床检查和MRI。术前平均国际膝关节文献委员会（IKDC）评分为29.9 ± 13.2，29 ± 4.1个月时为85.4 ± 4.2（p < 0.0005），而术前膝关节损伤和骨关节炎结局评分（KOOS）为35.1 ± 11.9，29 ± 4.1个月时为87.3 ± 7.3（p < 0.0005）。对照MRI和活检样本显示病变部位的骨软骨再生。在3年的随访中，一步技术似乎是治疗OLK的良好且可靠的选择。证据等级病例系列，IV级。
Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients' posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9 ± 13.2 and 85.4 ± 4.2 at 29 ± 4.1 months (p < 0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1 ± 11.9 and 87.3 ± 7.3 at 29 ± 4.1 months (p < 0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV.