Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race.
Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race.
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DOI：
10.1532/lh96.04010
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发表时间：
2004-01-01
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影响因子：
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通讯作者：
van Assendelft, Onno W
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文献类型：
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作者：
Cheng, Calvino Ka-Wing;Chan, Julie;van Assendelft, Onno W
背景：对北美人群进行全面的、最新的“健康相关”参考区间研究并不常见。第三次美国国民健康和营养检查调查(NHANES III)于1994年结束，并产生了重要的参考区间数据。目的：从NHANES III获得按年龄、性别和种族划分的与健康相关的库尔特计数器参考区间数据。方法：在参加NHANES III的29,314名非住院美国公民中，约有25,000人在COURTER S-Plus JR上进行了全血细胞计数、红细胞分布宽度、血小板计数和自动白细胞差值测定。为了确定与健康相关的参考区间，我们使用了以下排除标准：怀孕、哺乳、肥胖(女性和男性的体重指数分别为40和35)，舒张压和舒张压分别为100 mm Hg，是否吸烟，是否饮酒，最近的贫血治疗，肌酐水平>；2.5 mg/dl，血糖水平>；126 mg/dL，过度消瘦(BMI 75岁)。结果：排除了高排除率；例如，在测得的20,685人中，12,688人(61.3%)被排除。几乎所有女性年龄/性别类别的百分位数估计值都可以准确得出。一些男性墨西哥裔美国人和非西班牙裔黑人的观察年龄在45岁到75岁之间。结论：许多测试都有年龄相关的趋势，特别是在RDW、MCMV、血小板计数、粒细胞和淋巴细胞百分比方面。与性别相关的变化包括血红蛋白值，以及以单核细胞和淋巴细胞百分比、红细胞压积、MCHC、MCH和血红蛋白为中心的种族相关趋势。这项研究揭示了使用大样本数据挖掘来产生潜在有用的参考范围的潜力。
BACKGROUND: Comprehensive, up-to-date "health-associated" reference interval studies of North American populations are uncommon. The third US National Health and Nutrition Examination Survey (NHANES III) was concluded in 1994 and yielded important reference interval data.OBJECTIVE: To obtain health-associated Coulter counter reference interval data from NHANES III according to age, sex, and race.METHODS: Of the 29,314 civilian noninstitutionalized US citizens who participated in NHANES III, approximately 25,000 had a complete blood count, red cell distribution width (RDW), platelet count, and automated white blood cell (WBC) differential determined on a Coulter S-Plus Jr. To determine health-associated reference intervals, we used the following exclusion criteria: pregnancy, breast feeding, obesity (body mass index [BMI] >40 and >35 for females and males, respectively), diastolic blood pressure >100 mm Hg, any smoking, any drinking of alcohol, recent treatment for anemia, creatinine level >2.5 mg/dL, glucose level >126 mg/dL, excessive thinness (BMI 75 years).RESULTS: There was a high exclusion rate; for example, of the 20,685 individuals with measured hemoglobin levels, 12,688 (61.3%) were excluded. Percentile estimates could be derived accurately for almost all of the female age/sex categories. A few of the male Mexican American and non-Hispanic black categories contained observations for ages 45 to 75 years.CONCLUSIONS: There are age-dependent trends for many of the tests, notably in RDW, MCMV, platelet count, and granulocyte and lymphocyte percentages. Sex-dependent changes involved hemoglobin values, and race-related trends centered around mononuclear and lymphocyte percentages, hematocrit, MCHC, MCH, and hemoglobin. This study reveals the potential for using data mining of large samples to yield potentially useful reference ranges.