Cold plasma-based control of the activation of pancreatic adenocarcinoma cells
Cold plasma-based control of the activation of pancreatic adenocarcinoma cells
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DOI：
10.1088/1361-6463/ab36d4
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发表时间：
2019-10-30
影响因子：
3.4
通讯作者：
Keidar, Michael
中科院分区：
文献类型：
--
作者：
Yan, Dayun;Lin, Li;Keidar, Michael
冷大气等离子体（CAP）在体内外均表现出较强的抗癌能力。CAP和癌细胞之间的相互作用为理解直接CAP治疗的抗癌作用奠定了基础。基于CAP的激活现象是理解CAP癌症治疗的关键因素。CAP处理的胰腺癌细胞瞬间进入特定的活化状态，其中这些癌细胞变得对活性氧和活性氮的细胞毒性非常敏感。在这里，我们提出了一个路线图控制的CAP射流的基本操作参数（氦气流量，放电电压，放电频率）的激活。在三个参数中，放电电压对活化现象的影响最大。当放电电压达到中等水平时，活化效果最大。一维化学模拟表明，这种最大的活化效应可能是由于在一定的放电电压下，CAP射流中的几种短寿命活性物种的最大密度。
Cold atmospheric plasma (CAP) has shown strong anti-cancer capability in vitro and in vivo. The interaction between CAP and cancer cells build the foundation to understand the anticancer effect of a direct CAP treatment. The CAP-based activation phenomenon is a key factor to understand the CAP cancer treatment. The CAP-treated pancreatic adenocarcinoma cells instantaneously entered a specific activation state, in which these cancer cells become very sensitive to the cytotoxicity of both reactive oxygen species and reactive nitrogen species. Here, we present a roadmap of control the basic operational parameters of the CAP jet (the helium flow rate, the discharge voltage, and the discharge frequency) on the activation. Among three parameters, the discharge voltage shows the largest impact on the activation phenomenon. The maximum activation effect occurred when the discharge voltage reached a medium level. A 0D chemical simulation revealed that such maximum activation effect may be due to the maximum densities of several short-lived reactive species in CAP jet at a certain level of discharge voltage.