T for two: when helpers need help.
T for two: when helpers need help.
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DOI：
10.1016/j.autrev.2005.04.001
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发表时间：
2005-11
影响因子：
13.6
通讯作者：
M. Zanetti
中科院分区：
文献类型：
--
作者：
M. Zanetti
This article discusses forms of cell cooperation involving CD4 T cells and their impact on adaptive immunity. In particular, evidence will be presented in favor of cooperation among CD4 T cells of different specificity, its molecular basis and functional significance. Th–Th cooperation, or help for helpers, will be discussed in relation to the induction of anti-tumor responses and, in converse, the generation of autoimmunity. A model is proposed where Th–Th cooperation may represent the structure/function substrate for the control of self/non-self discrimination and peripheral tolerance in vivo.
