FlyBase: establishing a Gene Group resource for Drosophila melanogaster.
FlyBase: establishing a Gene Group resource for Drosophila melanogaster.
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DOI：
10.1093/nar/gkv1046
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
FlyBase Consortium
中科院分区：
文献类型：
--
作者：
Attrill H;Falls K;Goodman JL;Millburn GH;Antonazzo G;Rey AJ;Marygold SJ;FlyBase Consortium
许多出版物描述了具有共同生物学特性的基因或基因产物的集合。例如，全基因组研究和系统发育分析确定了序列相关的基因;高通量遗传和分子筛选揭示了功能相关的基因产物;先进的蛋白质组学方法可以确定多蛋白质复合物的亚基组成。将这些基因集合作为适当的模式生物数据库（MOD）中的离散列表呈现是有用的，以便研究人员可以容易地访问这些数据以及其他相关信息。为此，果蝇MOD FlyBase（flybase.org）建立了一个“基因组”资源：来自已发表文献的高质量基因组，并组织成单独的报告页面。为了便于进一步分析，基因组报告还包括方便的下载和分析选项，以及与其他数据库中等效基因组的链接。这个新的资源将使具有不同背景和兴趣的研究人员能够轻松地查看和分析公认的D。黑腹果蝇基因组，并将它们与其他物种的基因组进行比较。
Many publications describe sets of genes or gene products that share a common biology. For example, genome-wide studies and phylogenetic analyses identify genes related in sequence; high-throughput genetic and molecular screens reveal functionally related gene products; and advanced proteomic methods can determine the subunit composition of multi-protein complexes. It is useful for such gene collections to be presented as discrete lists within the appropriate Model Organism Database (MOD) so that researchers can readily access these data alongside other relevant information. To this end, FlyBase (flybase.org), the MOD for Drosophila melanogaster, has established a ‘Gene Group’ resource: high-quality sets of genes derived from the published literature and organized into individual report pages. To facilitate further analyses, Gene Group Reports also include convenient download and analysis options, together with links to equivalent gene groups at other databases. This new resource will enable researchers with diverse backgrounds and interests to easily view and analyse acknowledged D. melanogaster gene sets and compare them with those of other species.