An implantable integrated low-power amplifier-microelectrode array for Brain-Machine Interfaces.
An implantable integrated low-power amplifier-microelectrode array for Brain-Machine Interfaces.
复制标题
用于脑机接口的植入式集成低功率放大器微电极阵列。
DOI：
10.1109/iembs.2010.5626419
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Nishida,Toshikazu
中科院分区：
文献类型：
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作者：
Patrick,Erin;Sankar,Viswanath;Rowe,William;Sanchez,JustinC;Nishida,Toshikazu
设计脑机接口（BMI）的重要挑战之一是建立能够可靠地处理大量皮质神经元活动的可植入系统。在本文中，我们报告了一种基于聚酰亚胺的微电极阵列的设计、制造和测试，该阵列集成了一个低功率放大器，作为佛罗里达大学佛罗里达无线集成记录电极（FWIRE）项目的一部分，该项目开发了一种用于BMI应用的完全植入式神经记录系统。电极阵列采用平面微加工MEMS工艺制作，并采用倒装键合技术与放大器芯片混合封装。该系统已在实验台上和体内进行了测试。对啮齿动物进行了为期42天的急性和慢性神经记录。在长期记录期间分析了电极放大器的性能，观察到噪声底限为4.5 μVrms，平均信噪比为3.8。
One of the important challenges in designing Brain-Machine Interfaces (BMI) is to build implantable systems that have the ability to reliably process the activity of large ensembles of cortical neurons. In this paper, we report the design, fabrication, and testing of a polyimide-based microelectrode array integrated with a low-power amplifier as part of the Florida Wireless Integrated Recording Electrode (FWIRE) project at the University of Florida developing a fully implantable neural recording system for BMI applications. The electrode array was fabricated using planar micromachining MEMS processes and hybrid packaged with the amplifier die using a flip-chip bonding technique. The system was tested both on bench and in-vivo. Acute and chronic neural recordings were obtained from a rodent for a period of 42 days. The electrode-amplifier performance was analyzed over the chronic recording period with the observation of a noise floor of 4.5 μVrms, and an average signal-to-noise ratio of 3.8.