Pregnancy in neuromyelitis optica spectrum disorder: A multicenter study from South China
Pregnancy in neuromyelitis optica spectrum disorder: A multicenter study from South China
复制标题
视神经脊髓炎谱系疾病的妊娠：华南地区的多中心研究
DOI：
10.1016/j.jns.2016.11.054
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发表时间：
2017-01-15
影响因子：
4.4
通讯作者：
Qiu, Wei
中科院分区：
文献类型：
--
作者：
Huang, Yanlu;Wang, Yule;Qiu, Wei
Objective: This study aimed to assess the effect of pregnancy on the course of neuromyelitis optica spectrum disorder (NMOSD), and the effect of this disease on pregnancy outcomes.Methods: Consecutive patients with NMOSD were recruited between September 2015 and April 2016 at an outpatient clinic from four referral institutes in South China. Demographic, clinical, and pregnancy data were retrieved by questionnaires to analyze the association between NMOSD and pregnancy, as well as the potential risk factors for relapse.Results: Among 249 patients with NMOSD, 55 had pregnancy-related attacks. The annual relapse rate in the first (3.20 +/- 6.82) and second (3.25 +/- 3.32) 3-month postpartum periods was marginally higher than that before pregnancy (1.44 +/- 0.92, p = 0.682) and during pregnancy (1.23 +/- 132, p = 0.758). The Kurtzke Expanded Disability Status Scale score increased from 1.55 +/- 0.38 before pregnancy to 2.88 +/- 2.14 at postpartum (p < 0.001). NMOSD significantly increased the premature birth rate in patients after disease onset (8.33%) compared with before disease onset (1.95%, p = 0.025). Multivariate analysis showed that negative anti-aquaporin-4 IgG, concomitance with autoimmune diseases/antibodies, and no treatment in remission were risk factors of recurrence.Conclusion: Our study shows a significant association between pregnancy and NMOSD in the Chinese population. Larger scale prospective studies are warranted in the future. (C) 2016 Elsevier B.V. All rights reserved.
