Purinergic system, microglia and neuropathic pain
Purinergic system, microglia and neuropathic pain
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DOI：
10.1016/j.coph.2011.10.014
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发表时间：
2012-02-01
影响因子：
4
通讯作者：
Inoue, Kazuhide
中科院分区：
文献类型：
--
作者：
Tsuda, Makoto;Tozaki-Saitoh, Hidetoshi;Inoue, Kazuhide
胞外核苷酸通过P2X受体（P2XRs）和P2Y受体（P2YRs）在神经系统的神经元和胶质功能调控中发挥关键作用。越来越多的证据表明，小胶质细胞表达P2XRs和P2YRs的几种亚型，这些受体在病理状态下，如周围神经损伤（神经性疼痛），在脊髓疼痛信号传导中起关键作用。周围神经损伤后，背角小胶质细胞被激活，嘌呤能受体表达上调，干扰嘌呤能受体的功能或表达强烈抑制神经性疼痛。这篇文章强调了最近的进展，进一步增加了我们对小胶质嘌呤能受体参与神经性疼痛发病机制的理解。
Extracellular nucleotides play pivotal roles in the regulation of neuronal and glial functions in the nervous system through P2X receptors (P2XRs) and P2Y receptors (P2YRs). A growing body of evidence shows that microglia express several subtypes of P2XRs and P2YRs, and that these receptors play a key role in pain signaling in the spinal cord under pathological conditions, such as following peripheral nerve injury (neuropathic pain). Following peripheral nerve injury, dorsal horn microglia become activated and show upregulated expression of purinergic receptors, and interference with the function or expression of these receptors strongly suppresses neuropathic pain. This article highlights recent advances that further increase our understanding of the mechanisms by which microglial purinergic receptors contribute to the pathogenesis of neuropathic pain.