Prognostic Factors in Treatment of Depressive States with Imipramine
Prognostic Factors in Treatment of Depressive States with Imipramine
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丙咪嗪治疗抑郁症的预后因素
DOI：
10.1136/bmj.1.5287.1225
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发表时间：
1962
影响因子：
--
通讯作者：
B.Sc R. F. GARSIDE
中科院分区：
文献类型：
--
作者：
M. D. L. G. KILOH;M. B. J. R. B. BALL;D.P.M Senior Registrar B.S.;B.Sc R. F. GARSIDE
在抑郁状态组内的准确诊断通常被认为是困难的。有些人否认困难，忽略它的存在，假设这些情况下形成一个均匀的连续。但是，即使是那些同意这一观点的人--例如Garmany（1958）--也承认治疗的结果不一致，而且，那些对E.C.T.有反应的人之间在生殖学上也存在差异，和那些没有的人丙咪嗪，正如许多临床试验（除了少数，唉，未经控制）所显示的那样，是治疗抑郁症的有效药物。然而，大量患者未能显示出对药物的任何持续反应。当一项双盲对照研究丙咪嗪对抑郁状态的影响时，
Accurate diagnosis within the group of depressive states is generally agreed to be difficult. Some deny the difficulty by ignoring its existence, assuming that these cases form a homogeneous continuum. But even those who share this belief-Garmany (1958) for instanceadmit discrepant results from treatment and, moreover, that there are differences in symptomatology between those -who respond, say, to E.C.T., and those who do not. Imipramine, as many clinical trials-all but a handful, alas, uncontrolled-have shown, is an effective agent in the treatment of depressive illness. However, substantial numbers of patients fail to show any sustained response to the drug. When a double-blind controlled study of the effects of imipramine upon depressive states was undertaken it