Mitochondrial reactive oxygen species as a mystery voice in hepatitis C
Mitochondrial reactive oxygen species as a mystery voice in hepatitis C
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DOI：
10.1111/hepr.12247
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发表时间：
2014-02
影响因子：
4.2
通讯作者：
K. Hino;Yuichi Hara;S. Nishina
中科院分区：
文献类型：
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作者：
K. Hino;Yuichi Hara;S. Nishina
有几条线索的证据表明，与其他炎症性肝病相比，丙型肝炎中存在的氧化应激程度更高，并且与疾病进展密切相关。活性氧（ROS）的主要产生位点被认为是线粒体，这一概念得到了丙型肝炎病毒（HCV）核心蛋白与线粒体直接相关的证据的支持。活性氧的解毒也是细胞氧化还原稳态系统的一个重要功能。这些结果引起了我们对HCV诱导的线粒体ROS产生如何超出氧化还原调节并影响慢性丙型肝炎患者肝细胞癌（HCC）的疾病进展和发展的关注。另一方面，HCV相关的慢性肝病以代谢改变为特征，如胰岛素抵抗、肝脂肪变性和/或肝脏铁积累。这些代谢紊乱也与HCV相关慢性肝病中HCC的发生有关。在这里，我们回顾了HCV增加线粒体ROS产生的机制，并就线粒体ROS如何与代谢紊乱（如胰岛素抵抗、肝脂肪变性和肝铁积累）联系提供了新的见解，这些代谢紊乱在HCV相关的慢性肝病中观察到。
There are several lines of evidence suggesting that oxidative stress is present in hepatitis C to a greater degree than in other inflammatory liver diseases and is closely related to disease progression. The main production site of reactive oxygen species (ROS) is assumed to be mitochondria, which concept is supported by evidence that hepatitis C virus (HCV) core protein is directly associated with them. The detoxification of ROS also is an important function of the cellular redox homeostasis system. These results draw our attention to how HCV‐induced mitochondrial ROS production is beyond redox regulation and affects the disease progression and development of hepatocellular carcinoma (HCC) in chronic hepatitis C. On the other hand, HCV‐related chronic liver diseases are characterized by metabolic alterations such as insulin resistance, hepatic steatosis and/or iron accumulation in the liver. These metabolic disorders also are relevant to the development of HCC in HCV‐related chronic liver diseases. Here, we review the mechanisms by which HCV increases mitochondrial ROS production and offer new insights as to how mitochondrial ROS are linked to metabolic disorders such as insulin resistance, hepatic steatosis and hepatic iron accumulation that are observed in HCV‐related chronic liver diseases.