Invasive Carcinoma Derived From Intestinal-Type Intraductal Papillary Mucinous Neoplasm Is Associated With Minimal Invasion, Colloid Carcinoma, and Less Invasive Behavior, Leading to a Better Prognosis
Invasive Carcinoma Derived From Intestinal-Type Intraductal Papillary Mucinous Neoplasm Is Associated With Minimal Invasion, Colloid Carcinoma, and Less Invasive Behavior, Leading to a Better Prognosis
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DOI：
10.1097/mpa.0b013e318214fa86
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发表时间：
2011-05-01
期刊：
影响因子：
2.9
通讯作者：
Oda, Yoshinao
中科院分区：
文献类型：
--
作者：
Nakata, Kohei;Ohuchida, Kenoki;Oda, Yoshinao
目的：虽然膀胱型导管内乳头状粘液癌（IPMC）有报道有较好的预后，很少有研究涉及其侵袭性模式。IPMC中“最小侵入”的含义也不清楚。我们研究了预后的导管内乳头状粘液性肿瘤（IPMN）集中在MI和亚型。方法：我们评估了71例IPMC中的179例IPMN切除术。结果：虽然10 MI-IPMC患者有2个淋巴结转移，有没有疾病特异性死亡的MI-IPMC患者。在肠型IPMC中观察到的微创IPMC（23/33例）比非肠型IPMC（16/38例; P = 0.019）更常见。在32例大规模侵袭性IPMC患者中，肠型IPMC患者的预后明显好于非肠型IPMC患者（P = 0.013）。当局限于大规模浸润性IPMC时，在腹膜型IPMC中观察到的小管浸润（P <0.001）和淋巴管（P = 0.001）或浆膜（P = 0.021）浸润的频率低于非肠型IPMC。结论：腹膜型IPMN来源的浸润性癌与MI、胶质癌和侵袭性较低的行为有关。
Objectives: Although intestinal-type intraductal papillary mucinous carcinoma (IPMC) is reported to have a better prognosis, few studies have addressed its invasive pattern. The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes.Methods: We evaluated 71 patients with IPMC among a total of 179 patients with resected IPMN.Results: Although 2 of 10 MI-IPMC patients had lymph node metastasis, there were no disease-specific deaths among the MI-IPMC patients. Minimally invasive IPMCs were more frequently observed in intestinal-type IPMC (23/33 cases) than in non-intestinal-type IPMCs (16/38 cases; P = 0.019). Among 32 patients with massively invasive IPMC, the prognosis was significantly better for patients with intestinal-type IPMC than for patients with non-intestinal-type IPMC (P = 0.013). When confined to massively invasive IPMC, tubular invasion (P < 0.001) and lymphatic (P = 0.001) or serosal (P = 0.021) invasion were less frequently observed in intestinal-type IPMC than in non-intestinal-type IPMC.Conclusions: Invasive carcinoma derived from intestinal-type IPMN is associated with MI, colloid carcinoma, and less invasive behavior.