Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake.
Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake.
复制标题
肝脏迷走神经传入传递时钟依赖性信号来调节昼夜节律食物摄入量。
DOI：
10.1101/2023.11.30.568080
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lazar,MitchellA
中科院分区：
文献类型：
--
作者：
Woodie,LaurenN;Melink,LilyC;Midha,Mohit;deAraújo,AlanM;Geisler,CarolineE;Alberto,AhrenJ;Krusen,BriannaM;Zundell,DelaineM;deLartigue,Guillaume;Hayes,MatthewR;Lazar,MitchellA
轮班或时差引起的昼夜节律不同步不利于代谢健康，但同步或不同步信号如何在组织之间传递尚不清楚。我们报告说，肝脏分子钟功能障碍通过肝迷走神经传入神经（HVAN）向大脑发出信号，导致食物摄入模式改变，并通过消融 HVAN 来纠正。肝分支迷走神经切断术还可以防止高脂肪饮食喂养引起的食物摄入中断并减少体重增加。我们的研究结果揭示了一种稳态反馈信号，该信号依赖于肝脏和大脑之间的通信来控制昼夜节律食物摄入模式。这表明肝迷走神经是时间紊乱情况下肥胖症的潜在治疗靶点。
Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but how synchronous or desynchronous signals are transmitted among tissues is unknown. We report that liver molecular clock dysfunction is signaled to the brain through the hepatic vagal afferent nerve (HVAN), leading to altered food intake patterns that are corrected by ablation of the HVAN. Hepatic branch vagotomy also prevents food intake disruptions induced by high-fat diet feeding and reduces body weight gain. Our findings reveal a homeostatic feedback signal that relies on communication between the liver and the brain to control circadian food intake patterns. This identifies the hepatic vagus nerve as a potential therapeutic target for obesity in the setting of chronodisruption.