Carcinoma ex basal cell adenoma of the parotid gland: A report of an extremely rare case
Carcinoma ex basal cell adenoma of the parotid gland: A report of an extremely rare case
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DOI：
10.1111/pin.12538
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发表时间：
2017-07-01
影响因子：
2.2
通讯作者：
Sugino, Takashi
中科院分区：
文献类型：
--
作者：
Kusafuka, Kimihide;Kawasaki, Takuya;Sugino, Takashi
由基底细胞腺瘤（BCA）引起的恶性非基底细胞瘤极为罕见。患者是一名72岁的日本男性，21年前发现左侧腮腺区肿胀。行浅表肺叶切除术。约60%的肿瘤由基底细胞组成的筛状和小梁组织组成，表现出轻微的异型性和核表达-catenin。这部分肿瘤被认为是BCA。在肿瘤的另一部分，观察到大量嗜酸性非典型细胞的增殖，其中大多数形成导管内结构。这些肿瘤细胞表现出细胞异型性，其中一些形成罗马桥结构或导致囊内浸润。免疫组化结果显示，这些细胞角蛋白7、总囊性疾病液蛋白15 （GCDFP-15）、雄激素受体（AR）和乳蛋白红蛋白（MMG）阳性，Ki-67标记指数高。因此，这部分肿瘤被认为是唾液管癌（SDC）。肿瘤的最终诊断是SDC前BCA（囊内型），这是非常罕见的。GCDFP-15、AR、MMG和Ki-67是诊断SDC前BCA的有效免疫组织化学标志物。
Malignant non-basaloid tumors that arise from basal cell adenoma (BCA) are extremely rare. The patient was a 72-year-old Japanese male, who had noticed swelling of the left parotid region 21 years ago. A superficial lobectomy was performed. About 60% of the tumor was made up of cribriform and trabecular tissue composed of basaloid cells, which exhibited mild atypia and nuclear expression of -catenin. This portion of the tumor was considered to be a BCA. In the other part of the tumor, the proliferation of large eosinophilic atypical cells, most of which formed intraductal structures, was observed. These tumor cells displayed cellular atypia, and some of them formed Roman bridge structures or contributed to intracapsular invasion. Immunohistochemically, these cells were positive for cytokeratin 7, gross cystic disease fluid proten-15 (GCDFP-15), androgen receptor (AR), and mammaglobin (MMG) and exhibited a high Ki-67 labeling index. So, this portion of the tumor was considered to be a salivary duct carcinoma (SDC). The tumor's final diagnosis was SDC ex BCA (intracapsular type), which is extremely rare. GCDFP-15, AR, MMG, and Ki-67 are useful immunohistochemical markers for diagnosing SDC ex BCA.