Wnt signaling maintains the hair-inducing activity of the dermal papilla.
Wnt signaling maintains the hair-inducing activity of the dermal papilla.
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DOI：
10.1101/gad.14.10.1181
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发表时间：
2000-05
影响因子：
10.5
通讯作者：
Jiro Kishimoto;R. Burgeson;Bruce A. Morgan
中科院分区：
文献类型：
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作者：
Jiro Kishimoto;R. Burgeson;Bruce A. Morgan
毛囊的形成及其周期性生长、静止和再生依赖于其表皮和真皮成分之间的相互信号传导。真皮组织中心，真皮乳头（DP），调节表皮毛囊的发育，并依赖于来自表皮的信号来发育和维持。在DP细胞的转基因小鼠中特异性表达的GFP被用来纯化这个群体，并研究所需的信号，以维持它。我们证明，特定的Wnt，但不是刺猬（嘘），保持生长期基因表达在体外和毛发诱导活性的皮肤重建试验。
The formation of the hair follicle and its cyclical growth, quiescence, and regeneration depend on reciprocal signaling between its epidermal and dermal components. The dermal organizing center, the dermal papilla (DP), regulates development of the epidermal follicle and is dependent on signals from the epidermis for its development and maintenance. GFP specifically expressed in DP cells of a transgenic mouse was used to purify this population and study the signals required to maintain it. We demonstrate that specific Wnts, but not Sonic hedgehog (Shh), maintain anagen-phase gene expression in vitro and hair inductive activity in a skin reconstitution assay.