Severe hypoglycemia from clarithromycin-sulfonylurea drug interaction.
Severe hypoglycemia from clarithromycin-sulfonylurea drug interaction.
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克拉霉素-磺酰脲药物相互作用导致严重低血糖。
作者：
R. Bussing;Amy Gende
我们报告两例严重低血糖发生在老年男性2型糖尿病谁是处方克拉霉素呼吸道感染。这两个人都有控制良好的糖尿病和轻度至中度肾功能受损。两个人都以相同的剂量服用克拉霉素，并且在开始使用抗生素后48小时内都发生了严重的低血糖。虽然许多药物已报告与磺脲类药物相互作用，导致低血糖，克拉霉素和磺脲类药物之间的相互作用尚未报告。我们讨论了这种潜在的严重反应的可疑机制，这是在治疗老年2型糖尿病患者的关注。
一名82岁的白色男性，有4个月的2型糖尿病病史，接受饮食和格列本脲5 mg每日一次治疗。他的血糖读数低于100（mg/dl）。他的合并症包括动脉粥样硬化性心脏病、高血压、轻度慢性肾衰竭伴肌酐1.6 mg/dl、肺气肿和膀胱癌。在当地急诊科（艾德），他被诊断为“支气管炎”，并开具克拉霉素，每日1,000 mg。在开始克拉霉素治疗后48小时，他变得无反应，Accucheck阅读为24 mg/dl。静脉注射给药…
We report two cases of severe hypoglycemia occurring in elderly men with type 2 diabetes who were prescribed clarithromycin for respiratory infections. Both individuals had well-controlled diabetes and mild to moderately impaired renal function. Both individuals were prescribed clarithromycin in identical dosages and both developed severe hypoglycemia within 48 h of starting the antibiotic. Although many drugs have been reported to interact with sulfonylureas causing hypoglycemia, the interaction between clarithromycin and a sulfonylurea has not been previously reported. We discuss the suspected mechanism for this potentially severe reaction which is of concern in the treatment of elderly patients with type 2 diabetes.
An 82-year-old white male with a 4-month history of type 2 diabetes was treated with diet and glyburide 5 mg daily. His blood glucose readings were in the low 100s (mg/dl). His comorbidities included atherosclerotic heart disease, hypertension, mild chronic renal failure with a creatinine of 1.6 mg/dl, emphysema, and bladder cancer. In a local emergency department (ED), he was diagnosed with “bronchitis” and prescribed clarithromycin, 1,000 mg daily. He became unresponsive with an Accucheck reading of 24 mg/dl, 48 h after starting clarithromycin. Administration of intravenous …