Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy
Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy
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铂纳米颗粒修饰的介孔二氧化硅用于药物输送和协同电动化疗
DOI：
10.1007/s12274-020-2838-1
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发表时间：
2020-05-23
期刊：
影响因子：
9.9
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Gu, Tongxu;Chen, Tong;Liu, Zhuang
电动疗法是本课题组最近提出的一种概念性的新的癌症治疗方法。在EDT过程中，铂纳米颗粒（PtNPs）在直流（DC）或方波交流（AC）电场的作用下，会发生电驱动的催化反应，产生活性氧（ROS）。为了进一步扩展EDT的潜力，我们在此设计了介孔二氧化硅基纳米复合材料，其用PtNPs修饰并负载抗癌药物阿霉素（DOX）用于协同电动化疗。这种基于二氧化硅的纳米复合材料能够均匀杀死大尺寸肿瘤（超过500 mm3），并在相对低的电量下实现显著的肿瘤破坏功效。据我们所知，这是第一项将联合收割机EDT和化疗结合起来开发协同纳米平台的研究，为其他基于EDT的抗癌策略的设计开辟了新的维度。
Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group. During EDT, the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave alternating current (AC) electric field. To further extend the potential of EDT, we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy. Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity. To our best knowledge, this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform, openning a new dimension for the design of other EDT-based anticancer strategies.