A pilot trial examining the absorption of oral forms of folate supplementation in a healthy population: A randomised control trial
A pilot trial examining the absorption of oral forms of folate supplementation in a healthy population: A randomised control trial
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DOI：
10.1016/j.aimed.2018.09.005
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发表时间：
2019-05-01
影响因子：
1.7
通讯作者：
Schloss, Janet
中科院分区：
文献类型：
--
作者：
Bayes, Jessica;Agrawal, Nitish;Schloss, Janet
背景和目标：叶酸补充剂通常由卫生专业人员处方用于许多不同的条件，然而，不同衍生物的吸收仍不清楚。这项试点试验的目的是评估吸收各种形式的叶酸补充剂在健康population.Methods：一个为期四周，单盲，随机对照试验进行了30名健康人。干预措施包括补充500 mcg叶酸、亚叶酸或5-甲基四氢叶酸（5-MTHF）。15名参与者被分配到干预组，15名被分配到对照组进行比较。在基线（第0周）完成病例报告，并进行血清叶酸，B12和MTHFR多态性的病理学检查。随访血清叶酸血液病理学测试进行了评估，在第2周和第4周沿着与额外的食物diares.Results：队列中，87%（n = 26）被发现有MTHFR基因多态性与A1298 C（n = 12）和C677 T（n = 18）正在测试。只有13%（n = 4）的参与者没有突变。在对照组和所有干预组中观察到不同的MTHFR突变。平均（+/- SD）基线叶酸为33.7 nmol/L +/- 7.55（参考范围：>9.0）。同时具有A1298 C和C677 T多态性的参与者的基线叶酸水平较低，平均值（+/- SD）为29 nmol/L +/- 8.75。在四周期间，在亚叶酸和5-MTHF组中均观察到平均血清叶酸的总体增加。亚叶酸干预组平均（+/- SD）增加15.3 nmol/L +/- 3.56，5-MTHF平均（+/- SD）增加9.1 nmol/L +/- 1.67，但在叶酸组中检测到平均血清叶酸盐降低。在亚叶酸和5-MTHF组，血清叶酸增加观察到的个人，无论他们的MTHFR status.Conclusions：这项研究提供了一个基础，为进一步的工作调查叶酸的吸收。试验结果表明，亚叶酸具有最好的吸收，然而，它可能没有最好的生物利用度。需要更多的研究来更好地澄清这些补充剂的吸收和生物利用度。(C)2018爱思唯尔有限公司版权所有
Background & aims: Folate supplements are commonly prescribed by health professionals for a number of different conditions, however, the absorption of the different derivatives remains unclear. This pilot trial aims to assess the absorption of various forms of folate supplements in a healthy population.Methods: A four-week, single blinded, randomised control trial was conducted on 30 healthy individuals. The intervention included supplementation with 500mcg of either folic acid, folinic acid or 5-Methyltetrahydrofolate (5-MTHF). Fifteen participants were allocated to the intervention and fifteen to the control group for comparison. At baseline (week 0) a case report was completed and pathology tests for serum folate, B12 and MTHFR polymorphisms were conducted. Follow up serum folate blood pathology tests were assessed at week 2 and week 4 along with additional food diaries.Results: Of the cohort, 87% (n = 26) were found to have a MTHFR polymorphism with both A1298C (n = 12) and C677 T (n = 18) being tested. Only13% (n = 4) of participants had no mutation. The different MTHFR mutations were observed across both the control group and all of the intervention groups. The mean (+/- SD) baseline folate was 33.7 nmol/L +/- 7.55 (Reference range: >9.0). Participants who had both A1298C and C677 T polymorphism had lower baseline folate with a mean (+/- SD) of 29 nmol/L +/- 8.75. During the four weeks an overall increase in mean serum folate was observed in both the folinic acid and 5-MTHF group. The folinic acid intervention saw a mean (+/- SD) increase of 15.3 nmol/L +/- 3.56 and 5-MTHF saw a mean (+/- SD) increase of 9.1 nmol/L +/- 1.67, however a decrease in mean serum folate was detected in the folic acid group. In the folinic acid and 5-MTHF groups, serum folate increases were observed in individuals irrespective of their MTHFR status.Conclusions: This research has provided a foundation for further work investigating folate absorption. The results of the trial suggest that folinic acid has the best absorption, however, it may not have the best bioavailability. More research is required for greater clarification regarding the absorption and bioavailability of these supplements. (C) 2018 Elsevier Ltd. All rights reserved.