Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice.
Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice.
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硫利达嗪治疗可预防克氏锥虫感染小鼠的心脏病。
DOI：
10.1016/j.ijantimicag.2003.10.006
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发表时间：
2004
影响因子：
10.8
通讯作者：
P. Paglini
中科院分区：
文献类型：
--
作者：
M. Presti;H. Rivarola;J. Bustamante;A. R. Fernández;J. Enders;R. Fretes;S. Gea;P. Paglini
克氏锥虫色氨硫酮还原酶是一种已被确定为潜在的化疗靶点的酶。硫代咪嗪可抑制其活性，并可预防感染图拉胡氏毛滴虫的小鼠的心脏病。由于并非所有克鲁兹毛滴虫菌株对治疗的反应都相同，因此使用了来自一名慢性患者的分离株(SGO Z12)；研究了寄生虫病以及存活率、血清学、心电图学、组织学和心脏β受体功能。硫代咪嗪(80 mg/(Kgday)，连续3天)治疗组小鼠的寄生虫血症较少，持续时间较短(P<；0.01)，心电图和组织学改变减轻，存活率显著提高(80%未治疗组死亡)。治疗的小鼠具有较低的受体亲和力和较高的密度作为一种代偿机制，改变了克氏毛滴虫的感染过程(SGO Z12分离株)，并预防了随后的心脏病。
Trypanosoma cruzi trypanothione reductase is an enzyme that has been identified as a potential target for chemotherapy. Thioridazine inhibits it and prevented cardiopathy in mice infected with T. cruzi Tulahuen strain. As not all T. cruzi strains respond to treatment in the same way, an isolate from a chronic patient (SGO Z12) was used; parasitaemias were studied along with, survival, serology, electrocardiography, histology and cardiac β receptor function. Parasitaemia in thioridazine (80mg/(kgday) for 3 days) treated mice was less and lasted for a shorter period (P<0.01), there were reduced electrocardiographic and histological alterations and significantly improved survival (80% of non-treated died). Treated mice had lower receptor affinity and higher density as a compensatory mechanism, modifying the course of T. cruzi infection (SGO Z12 isolate) and preventing the consequent cardiopathy.