Mechanisms for initiating cellular DNA replication.
Mechanisms for initiating cellular DNA replication.
复制标题
DOI：
10.1146/annurev-biochem-052610-094414
复制
发表时间：
2013
影响因子：
16.6
通讯作者：
Berger JM
中科院分区：
文献类型：
--
作者：
Costa A;Hood IV;Berger JM
DNA复制的起始代表了细胞增殖的一个承诺步骤。适当的复制起始依赖于多蛋白复合物，这些复合物有助于正确区分起始区域，产生新生的复制泡，并促进复制体形成。本文综述了细菌、古生菌和真核生物所采用的起始系统，重点比较和对比了生物体之间的分子机制。虽然可以找到共同的功能领域和策略，用于执行和规范启动，许多关键参与者有显着不同的活动，似乎已经趋同发展。尽管该领域取得了重大进展，但在理解启动程序如何在分子水平上执行方面仍然存在重大问题。
The initiation of DNA replication represents a committing step to cell proliferation. Appropriate replication onset depends on multiprotein complexes that help properly distinguish origin regions, generate nascent replication bubbles, and promote replisome formation. This review describes initiation systems employed by bacteria, archaea, and eukaryotes, with a focus on comparing and contrasting molecular mechanisms among organisms. Although commonalities can be found in the functional domains and strategies used to carry out and regulate initiation, many key participants have markedly different activities and appear to have evolved convergently. Despite significant advances in the field, major questions still persist in understanding how initiation programs are executed at the molecular level.