ALPHA-1-ACID GLYCOPROTEIN CONCENTRATION AND THE PROTEIN-BINDING OF DISOPYRAMIDE IN HEALTHY-SUBJECTS
ALPHA-1-ACID GLYCOPROTEIN CONCENTRATION AND THE PROTEIN-BINDING OF DISOPYRAMIDE IN HEALTHY-SUBJECTS
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DOI：
10.1002/j.1552-4604.1995.tb04096.x
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发表时间：
1995-05-01
影响因子：
2.9
通讯作者：
MIYAZAKI, K
中科院分区：
文献类型：
--
作者：
KISHINO, S;NOMURA, A;MIYAZAKI, K
在加强体检后，检测与年龄和性别相关的血清α(1)-酸性糖蛋白(AAG)浓度和异丙吡胺的血清蛋白结合力。根据51分以上的临床生化指标，245例诊断为健康者，71例(22.5%)至少有一项指标出现异常。在健康者中，男性的血清AAG浓度显著高于女性(男性为0.78+/-0.18 mg/mL，均值为+/-SD；女性为0.67+/-0.16 mg/mL)。相比之下，男性和女性年龄组之间的AAG浓度和异丙吡胺的未结合部分没有显著差异。性别改变AAG浓度。然而，年龄不会改变AAG的浓度和基础药物的蛋白质结合。
Age- and gender-related changes in serum alpha(1)-acid glycoprotein (AAG) concentration and the serum protein binding of disopyramide were examined after intensive medical examination. Based on the clinical chemistry tests over 51 points, 245 subjects were diagnosed as healthy and 71 subjects (22.5%) revealed an abnormal value for at least one item, In the healthy subjects, serum AAG concentration in men was significantly higher than in women (men, 0.78 +/- 0.18 mg/mL, mean +/- SD; women, 0.67 +/- 0.16 mg/mL. In contrast, there were no significant differences in the AAG concentration between age groups for men and women and in the unbound fraction of disopyramide. Gender changes AAG concentration. Age, however, does not change AAG concentration and the protein binding of the basic drug.