Aluminum Doped MCM-41 Nanoparticles as Platforms for the Dual Encapsulation of a CO-Releasing Molecule and Cisplatin
Aluminum Doped MCM-41 Nanoparticles as Platforms for the Dual Encapsulation of a CO-Releasing Molecule and Cisplatin
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DOI：
10.1021/acs.inorgchem.7b01475
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发表时间：
2017-09-04
影响因子：
4.6
通讯作者：
Barea, Elisa
中科院分区：
文献类型：
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作者：
Carmona, Francisco J.;Jimenez-Amezcua, Ignacio;Barea, Elisa
介孔二氧化硅Al-MCM-41纳米颗粒已首次用作阳离子CO释放分子（CORM）[Mn（1，4，7，三氮杂环壬烷）（CO）（3）]（+）（ALF 472（+））和众所周知的顺铂药物cis-[PtCL 2（NH 3）（2）]（顺铂）的单包封和双包封的载体。因此，两种新的杂化材料，即ALF 472 @Al-MCM-41和ALF 472-cisplatin@ Al-MCM-41，已被分离和充分表征。结果表明，CORM分子的存在使顺铂负载增强3倍，产生0.45 mmol g（-1）的ALF 472（+）和0.12 mmol g（-1）的ALF 472-顺铂@Al-MCM-41的铂络合物的负荷。值得注意的是，ALF472@A1-MCM-41在磷酸盐缓冲盐水溶液中显示出良好的分散性，而双杂合材料在该模拟生理介质中轻微聚集（流体动力学尺寸：分别为112 +/-23和336 +/-50 nm）。此外，两种杂化材料（ALF 472 @Al-MCM-41和ALF 472-顺铂@Al-MCM-41）表现为光活性CO释放材料，在24小时后分别递送0.25和0.11当量的CO，并且表现出比游离CORM更可控的CO递送。最后，金属浸出研究已经证实了Al-MCM-41对潜在毒性锰碎片的良好保留能力（72小时后保留86%）以及顺铂的低释放（约20%）。72 h后7%）。
Mesoporous silica Al-MCM-41 nanoparticles have been used, for the first time, as vehicles for the single and dual encapsulation of the cationic CO-releasing molecule (CORM) [Mn(1,4,7,triazacyclononane)(CO)(3)](+) (ALF472(+)) and the well-known antineoplastic drug, cis-[PtCL2(NH3)(2)] (cisplatin). Thus, two new hybrid materials, namely, ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41, have been isolated and fully characterized. The results reveal that the presence of CORM molecules enhances cisplatin loading 3 fold, yielding a cargo of 0.45 mmol g(-1) of ALF472(+) and 0.12 mmol g(-1) of the platinum complex for ALF472-cisplatin@Al-MCM-41. It is worth noting that ALF472@A1-MCM-41 shows a good dispersion in phosphate buffered saline solution, while the dual hybrid material slightly aggregates in this simulated physiological medium (hydrodynamic size: 112 +/- 23 and 336 +/- 50 nm, respectively). In addition, both hybrid materials (ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41) behave as photoactive CO-releasing materials, delivering 0.25 and 0.11 equiv of CO, respectively, after 24 h and exhibiting a more controlled CO delivery than that of the free CORM. Finally, metal leaching studies have confirmed the good retention capacity of Al-MCM-41 toward the potentially toxic manganese fragments (86% of retention after 72 h) as well as the low release of cisplatin (ca. 7% after 72 h).