Expression of MHC class I and β2-microglobulin in rat spinal motoneurons:: Regulatory influences by IFN-gamma and axotomy
Expression of MHC class I and β2-microglobulin in rat spinal motoneurons:: Regulatory influences by IFN-gamma and axotomy
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DOI：
10.1006/exnr.1997.6768
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发表时间：
1998-04-01
影响因子：
5.3
通讯作者：
Olsson, T
中科院分区：
文献类型：
--
作者：
Lindå, H;Hammarberg, H;Olsson, T
MHC抗原的低表达被认为是导致中枢神经系统神经元免疫应答状态的重要因素之一。与之相反，成年大鼠腰髓内运动神经元同时表达MHC-I类和β2-微球蛋白mRNA，运动神经元也显示有干扰素-γ受体mRNA的原位杂交信号，切断外周轴突后，运动神经元表达明显上调。用干扰素-γ处理培养的大鼠胚胎脊髓运动神经元，会引起类似的上调，特别是β2-微球蛋白。基于这些事实，我们认为脊髓运动神经元可以受到干扰素-γ的影响，并被细胞毒CD8+T细胞识别。这些发现可能对寻找运动神经元特异性疾病(如ALS)的致病机制具有重要意义。(C)1998年学术出版社。
The low expression of MHC antigens is believed to be one factor of importance contributing to the immune-priveleged status of CNS neurons. We here describe that motoneurons, in contrast; to other nerve cells in the lumbar spinal cord of the adult rat, express both MHC class I and beta 2-microglobulin mRNA, The motoneurons also display in situ hybridization signal for IFN-gamma receptor mRNA, After a peripheral axotomy, the motoneurons show a clear upregulation of beta 2-microglobulin mRNA. IFN-gamma treatment of cultured rat embryonic spinal motoneurons causes a similar upregulation of especially beta 2-microglobulin. Based on these facts, we propose that spinal motoneurons can be influenced by IFN-gamma and recognized by cytotoxic CD8+ T-cells. These findings could be of relevance in the search for pathogenetic mechanisms in motoneuron-specific diseases, such as ALS. (C) 1998 Academic Press.