Topical inhibition of oral carcinoma cell with polymer delivered celecoxib.
Topical inhibition of oral carcinoma cell with polymer delivered celecoxib.
复制标题
用聚合物递送的塞来昔布局部抑制口腔癌细胞。
DOI：
10.1016/s0304-3835(03)00272-6
复制
发表时间：
2003
期刊：
影响因子：
9.7
通讯作者：
Shapshay,StanleyM
中科院分区：
文献类型：
--
作者：
Wang,Zhi;Polavaram,Raju;Shapshay,StanleyM
Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral carcinoma cells. Seventeen nude mice were intradermally inoculated with the carcinoma cells, and then were divided into control and treatment groups. Tumor growth was measured for 15 days, at which significant difference was found between two groups (P<0.001). This study indicates a potential role of polymer film delivered celecoxib for topical inhibition of oral cancer.
