Hypoxia-related lipid peroxidation:: Evidences, implications and approaches
Hypoxia-related lipid peroxidation:: Evidences, implications and approaches
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DOI：
10.1016/j.resp.2007.06.001
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发表时间：
2007-09-30
影响因子：
2.3
通讯作者：
Gonzalez, Gustavo
中科院分区：
文献类型：
--
作者：
Behn, Claus;Araneda, Oscar R.;Gonzalez, Gustavo
缺氧可能会加剧并发氧化应激。与有氧ATP需求相关的缺氧，如缺氧所定义的，沿着活性氧（ROS）的产生增加。多不饱和脂肪酸（PUFA）是最易受ROS影响的分子之一。n-3 PUFA的氧化分解不仅可能损害膜脂质基质动力学，因此损害膜相关蛋白如酶、受体和转运蛋白的结构和功能，而且可能损害基因表达。二十碳五烯酸消耗、脂质过氧化（LP）产物以及缺氧可能联合收割机加重核因子κ B（NF κ B B）的活性，NF κ B是一种普遍存在的促炎和抗凋亡转录因子。在高海拔地区的野外研究表明，登山运动员呼出气冷凝物（EBC）中的丙二醛（MDA）含量与急性高原病的路易斯湖评分相关。因此，可以预期LP在缺氧中的致病作用。通过控制LP，一些物种似乎比其他物种更有效地科普自然发生的缺氧。通过提供足够的n-3 PUFA和抗氧化剂限制缺氧相关LP的潜在促炎作用，可能有助于在与有氧ATP需求相关的缺氧条件下增加存活率。然而，抗氧化剂干预的需要应与触发适应性过程以响应增加的氧气需求的ROS需求相权衡。(c)2007 Elsevier B. V.保留所有权利。
Hypoxia may be intensified by concurrent oxidative stress. Lack of oxygen in relation to aerobic ATP requirements, as hypoxia has been defined, goes along with an increased generation of reactive oxygen species (ROS). Polyunsaturated fatty acids (PUFAs) range among the molecules most susceptible to ROS. Oxidative breakdown of n-3 PUFAs may compromise not only membrane lipid matrix dynamics, and hence structure and function of membrane-associated proteins like enzymes, receptors, and transporters, but also gene expression. Eicosapentaenoic acid depletion, products of lipid peroxidation (LP), as well as, lack of oxygen may combine in exacerbating activity of nuclear factor kappa B (NF kappa B), an ubiquitous pro-inflammatory and anti-apoptotic transcription factor. Field studies at high altitude show malondialdehyde (MDA) content in exhaled breath condensate (EBC) of mountaineers to correlate with Lake Louis score of acute mountain sickness. A pathogenic role of LP in hypoxia can therefore be expected. By control of LP, some species seem to cope more efficiently than others with naturally occurring hypoxia. Limitation of potential pro-inflammatory effects of hypoxia-related LP by an adequate provision of n-3 PUFAs and antioxidants may contribute to increase survival under conditions where oxygen is lacking in relation to aerobic ATP requirements. A need for antioxidant intervention, however, should be weighed against the ROS requirement for triggering adaptive processes in response to an increased demand of oxygen. (c) 2007 Elsevier B.V. All rights reserved.