Dentate granule and mossy cells exhibit distinct spatiotemporal responses to local change in a one-dimensional landscape of visual-tactile cues
Dentate granule and mossy cells exhibit distinct spatiotemporal responses to local change in a one-dimensional landscape of visual-tactile cues
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DOI：
10.1038/s41598-019-45983-6
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发表时间：
2019-07-02
影响因子：
4.6
通讯作者：
Royer, Sebastien
中科院分区：
文献类型：
--
作者：
Jung, Dajung;Kim, Soyoun;Royer, Sebastien
齿状回（DG）是检测环境变化的关键;然而，颗粒细胞（GC）和苔藓细胞（MC），DG的两种兴奋性细胞类型，如何对物体布局的微小变化作出反应尚不清楚。在这里，我们记录了GC和MC，通过尖峰特征和光遗传学标记来识别，因为小鼠在富含视觉-触觉线索的跑步机带上跑步。我们观察到，固定一个新的线索带诱导的GC和MC的空间表示的重新配置通过出现，灭绝和率改变的射击场。对于GC和MC，响应是最大的线索附近，并蔓延到整个带。然而，GC的反应相比，MC的反应更强，更直接，在稍早的带位置达到峰值，并表现出短暂的组成部分，让人想起神经调节活性。一个竞争性的神经网络模型再现的GC响应，无论是新的对象向量输入和MC活动的重新配置，前者是至关重要的GC响应在远离线索的位置传播。这些研究结果表明，GC作为一个竞争网络，MC先于GC检测变化，并有助于扩大GC模式分离的范围。
The dentate gyrus (DG) is critical for detecting changes in environments; however, how granule cells (GCs) and mossy cells (MCs), the two excitatory cell types of the DG, respond to small changes in the object layout is unclear. Here, we recorded GCs and MCs, identified by spike feature and optogenetic tagging, as mice ran on a treadmill belt enriched with visual-tactile cues. We observed that fixing a new cue on the belt induced a reconfiguration of GC and MC spatial representations via the emergence, extinction and rate alteration of firing fields. For both GCs and MCs, the response was maximal near the cue and spread over the entire belt. However, compared to the GC response, the MC response was stronger and more immediate, peaked at a slightly earlier belt position, and exhibited a transient component reminiscent of neuromodulatory activity. A competitive neural network model reproduced the GC response contingent on both the introduction of new object-vector inputs and the reconfiguration of MC activity, the former being critical for spreading the GC response in locations distant from the cue. These findings suggest that GCs operate as a competitive network and that MCs precede GCs in detecting changes and help expand the range of GC pattern separation.