Identification of synergistic signals initiating inner ear development
Identification of synergistic signals initiating inner ear development
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DOI：
10.1126/science.290.5498.1965
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发表时间：
2000-12-08
期刊：
影响因子：
56.9
通讯作者：
Francis-West, PH
中科院分区：
文献类型：
--
作者：
Ladher, RK;Anakwe, KU;Francis-West, PH
50多年前在两栖动物身上进行的组织操纵实验表明，内耳的诱导需要两个信号：一个是中胚层信号，一个是神经信号。然而，介导这一过程的分子仍然难以捉摸。我们提供了高等脊椎动物耳朵发育的中胚层起始的证据，并表明中胚层可以指导吻侧外胚层内耳的终末分化。此外，我们证明了细胞外多肽配体FGF-19和Wnt-8c分别作为中胚层和神经信号的介质，启动内耳发育的协同相互作用。
Tissue manipulation experiments in amphibians more than 50 years ago showed that induction of the inner ear requires two signals: a mesodermal signal followed by a neural signal. However, the molecules mediating this process have remained elusive. We present evidence for mesodermal initiation of otic development in higher Vertebrates and show that the mesoderm can direct terminal differentiation of the inner ear in rostral ectoderm. Furthermore, we demonstrate the synergistic interactions of the extracellular polypeptide ligands FGF-19 and Wnt-8c as mediators of mesodermal and neural signals, respectively, initiating inner ear development.