Behavioural Pharmacology in Classical Conditioning of the Proboscis Extension Response in Honeybees (Apis mellifera)
Behavioural Pharmacology in Classical Conditioning of the Proboscis Extension Response in Honeybees (Apis mellifera)
复制标题
DOI：
10.3791/2282
复制
发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Eisenhardt, Dorothea
中科院分区：
文献类型：
--
作者：
Felsenberg, Johannes;Gehring, Katrin B.;Eisenhardt, Dorothea
蜜蜂（Apis mellifera）以其沟通和定向技能以及令人印象深刻的学习能力而闻名（1，2）。由于蜂群的生存依赖于食物来源的开发，觅食蜜蜂学习和记忆可变的花址以及它们的盈利能力。觅食蜂可以很容易地在自然环境中训练，它们在喂食点觅食，并学习相关的信号，如气味或颜色。在实验室的受控条件下，也可以通过调节单独驾驭蜜蜂的喙延伸反应（PER）来研究食欲联想学习（3，4）。这种学习范式使得能够以简单且高度可靠的方式研究学习和记忆形成的神经元和分子机制（5-12）。行为药理学方法用于研究分子机制。在学习和记忆形成期间或之后，全身注射药物以干扰特定分子的功能（13-16）。
Honeybees (Apis mellifera) are well known for their communication and orientation skills and for their impressive learning capability(1,2).Because the survival of a honeybee colony depends on the exploitation of food sources, forager bees learn and memorize variable flower sites as well as their profitability. Forager bees can be easily trained in natural settings where they forage at a feeding site and learn the related signals such as odor or color. Appetitive associative learning can also be studied under controlled conditions in the laboratory by conditioning the proboscis extension response (PER) of individually harnessed honeybees(3,4). This learning paradigm enables the study of the neuronal and molecular mechanisms that underlie learning and memory formation in a simple and highly reliable way(5-12). A behavioral pharmacology approach is used to study molecular mechanisms. Drugs are injected systemically to interfere with the function of specific molecules during or after learning and memory formation(13-16).