Inferences on the kinetics of asbestos deposition and clearance among chrysotile miners and millers
Inferences on the kinetics of asbestos deposition and clearance among chrysotile miners and millers
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DOI：
10.1002/(sici)1097-0274(199904)35:4
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发表时间：
1999-04-01
影响因子：
3.5
通讯作者：
Dufresne, A
中科院分区：
文献类型：
--
作者：
Finkelstein, MM;Dufresne, A
背景：石棉对健康的影响与吸入纤维在肺中的命运密切相关。石棉纤维的动力学主要在啮齿动物中进行了研究。本研究的目的是探讨这些动力学模型的应用，以人类尸检data.Methods：我们分析了72魁北克温石棉矿工和米莱尔和49个对照组的肺石棉纤维含量，使用分析透射电子显微镜。统计方法包括标准的多元线性回归和局部加权回归methods.Results：石棉机构和温石棉和透闪石纤维的肺负担相关的是每个石棉品种的短，中，长纤维的浓度。职业接触的持续时间与温石棉和透闪石的负荷之间存在着显著的关联。温石棉的浓度随着暴露时间的延长而降低，而透闪石的浓度则不随暴露时间的延长而降低。清除率与纤蛇纹石纤维的长度成反比。对于纤维大于10亩的长度清除半衰期估计为8 years.Conclusions：在我们的数据中的模式是兼容的假设，建议从啮齿动物实验，存在一个长期的隔离室和超载的清除机制在这个车厢。Am. J. Ind. Med. 35：401-412，1999. (C)1999 Wiley-Liss，Inc.
Background: The health effects of asbestos are intimately related to the fate of inhaled fibers in the lungs. The kinetics of asbestos fibers have been studied primarily in rodents. The objective of this study was to explore the application of these kinetic models to human autopsy data.Methods: We analyzed the asbestos fiber content of the lungs of 72 Quebec chrysotile miners and millers and 49 control subjects using analytical transmission electron microscopy. Statistical methods included standard multivariate linear regression and locally weighted regression methods.Results: The lung burdens of asbestos bodies and chrysotile and tremolite fibers were correlated as were the concentrations of short, medium, and long fibers of each asbestos variety. There were significant associations between the duration of occupational exposure and the burdens of chrysotile and tremolite. The concentration of chrysotile decreased with the time since last exposure but the concentration of tremolite did not. The clearance rate varied inversely with the length of chrysotile fibers. For fibers greater than 10 mu in length the clearance half-time was estimated to be 8 years.Conclusions: The patterns in our data are compatible with both of the hypotheses suggested from rodent experiments; the existence of a long-term sequestration compartment and overload of clearance mechanisms in this compartment. Am. J. Ind. Med. 35:401-412, 1999. (C) 1999 Wiley-Liss, Inc.