Modulating apical-basal polarity by building and deconstructing a Yurt.
Modulating apical-basal polarity by building and deconstructing a Yurt.
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通过建造和解构蒙古包来调节顶端-基底极性。
DOI：
10.1083/jcb.201810059
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Peifer,Mark
中科院分区：
文献类型：
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作者：
Perez-Vale,KiaZ;Peifer,Mark
细胞极性是由顶端和底外侧结构域的蛋白质网络调节的，它们通过相互拮抗的相互作用相互抑制。Gamblin et al.(2018。[j]细胞生物学。https://doi.org/10.1083/jcb.201803099)表明，基部外侧Yurt的寡聚化可以拮抗顶端碎屑，而Yurt的寡聚化反过来又受到顶端激酶aPKC的负调控。
Cell polarity is regulated by protein networks in the apical and basolateral domains that repress one another by mutually antagonistic interactions. Gamblin et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201803099) reveal that apical Crumbs is antagonized by oligomerization of basolateral Yurt, while Yurt oligomerization is in turn negatively regulated by the apical kinase aPKC.