Functional Cliques in the Amygdala and Related Brain Networks Driven by Fear Assessment Acquired During Movie Viewing
Functional Cliques in the Amygdala and Related Brain Networks Driven by Fear Assessment Acquired During Movie Viewing
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DOI：
10.1089/brain.2011.0061
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发表时间：
2011-12-01
影响因子：
3.4
通讯作者：
Hendler, Talma
中科院分区：
文献类型：
--
作者：
Kinreich, Sivan;Intrator, Nathan;Hendler, Talma
研究恐惧的大脑机制所涉及的最大挑战之一是捕捉个体独特的瞬时体验。到目前为止，脑成像研究通常会牺牲关于个体实时意识体验的有价值的信息，特别是在专注于阐明杏仁核的活动时。在这里，我们假设，通过使用最小干扰的线索以及应用稳健的聚类方法来探测杏仁核，将有可能实时评估恐惧并得出相关的激活网络。在功能性磁共振成像扫描期间，健康志愿者观看了恐怖电影的两个节选，并定期接受听觉提示，以评估他们瞬间感受到的“我很害怕”。利用图论和社区数学概念，杏仁核中与恐惧相关的功能集团的数据驱动聚类是在个别标记的恐惧加剧时期的指导下进行的。来自这些杏仁核激活集团的个别定制功能随后被用作一般线性模型预测因子，用于全脑分析，以揭示相关网络。我们的结果表明，通过使用局部稳健的聚类方法，有可能探测到与个体实时情绪体验直接相关的右侧杏仁背核的激活。此外，这种恐惧引发的杏仁核揭示了两个相互对立的共同激活和共同去激活的网络，分别对应于警觉和休息相关的回路。
One of the greatest challenges involved in studying the brain mechanisms of fear is capturing the individual's unique instantaneous experience. Brain imaging studies to date commonly sacrifice valuable information regarding the individual real-time conscious experience, especially when focusing on elucidating the amygdala's activity. Here, we assumed that by using a minimally intrusive cue along with applying a robust clustering approach to probe the amygdala, it would be possible to rate fear in real time and to derive the related network of activation. During functional magnetic resonance imaging scanning, healthy volunteers viewed two excerpts from horror movies and were periodically auditory cued to rate their instantaneous experience of "I'm scared.'' Using graph theory and community mathematical concepts, data-driven clustering of the fear-related functional cliques in the amygdala was performed guided by the individually marked periods of heightened fear. Individually tailored functions derived from these amygdala activation cliques were subsequently applied as general linear model predictors to a whole-brain analysis to reveal the correlated networks. Our results suggest that by using a localized robust clustering approach, it is possible to probe activation in the right dorsal amygdala that is directly related to individual real-time emotional experience. Moreover, this fear-evoked amygdala revealed two opposing networks of co-activation and co-deactivation, which correspond to vigilance and rest-related circuits, respectively.