The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes The CODAM study
The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes The CODAM study
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DOI：
10.1160/th15-05-0439
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发表时间：
2016-02-01
影响因子：
6.7
通讯作者：
van Greevenbroek, Marleen M. J.
中科院分区：
文献类型：
--
作者：
Hertle, Elisabeth;Arts, Ilja C. W.;van Greevenbroek, Marleen M. J.
补体激活的旁路途径是高度反应性的，并且可以在脉管系统中自发激活。激活可能导致血管损伤和心血管疾病（CVD）的发展。我们的目的是研究心血管风险中旁路途径的功能成分。我们研究了573人，他们被随访了7年。在基线时，我们测量了增强子备解素、限速蛋白酶因子D（FD）和系统激活标志物Bb。使用广义估计方程，我们研究了它们与心血管事件（CVE，N=89）、CVD（N=159）、低度炎症（LGI）、内皮功能障碍（艾德）和颈动脉内膜中层厚度（cIMT）的纵向相关性。此外，我们调查了342名基线时无CVD的参与者与事件CVE（N=39）和CVD（N=73）的相关性。CVE包括心肌梗死、卒中、心脏血管成形术和/或心脏搭桥术。CVD还包括心电图和/或踝臂指数显示的缺血
The alternative pathway of complement activation is highly reactive and can be activated spontaneously in the vasculature. Activation may contribute to vascular damage and development of cardiovascular disease (CVD). We aimed to investigate functional components of the alternative pathway in cardiovascular risk. We studied 573 individuals who were followed-up for seven years. At baseline, we measured the enhancer properdin; the rate-limiting protease factor D (FD); and a marker of systemic activation, Bb. Using generalised estimating equations, we investigated their longitudinal associations with cardiovascular events (CVE, N=89), CVD (N=159), low-grade inflammation (LGI), endothelial dysfunction (ED) and carotid intima-media thickness (cIMT). Furthermore, we investigated associations with incident CVE (N=39) and CVD (N=73) in 342 participants free of CVD at baseline. CVE included myocardial infarction, stroke, cardiac angioplasty and/or cardiac bypass. CVD additionally included ischaemia on an electrocardiogram and/or ankle-brachial index