Analysis of Multiple Ordinal Outcomes in Developmental Toxicity Studies
Analysis of Multiple Ordinal Outcomes in Developmental Toxicity Studies
复制标题
发育毒性研究中多个顺序结果的分析
DOI：
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复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
S. Lipsitz
中科院分区：
文献类型：
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作者：
Paige L. Williams;G. Molenberghs;S. Lipsitz
每只动物的反应。在本文中，我们考虑进行热休克研究，以评估小鼠胚胎体外暴露于不同水平和持续时间的热应激的影响，其中感兴趣的结果包括一系列按顺序分类的形态参数。已经提出了发育毒性领域的几种方法来评估多种二元或连续发育结局;然而，这种策略尚未充分开发用于多种有序结局。我们提出了一个边际建模框架，适用于相关的顺序响应，指定单变量累积概率为每个结果沿着与成对和高阶协会。最大似然法和准似然法估计参数的兴趣，并讨论其相对的优点和局限性的背景下，热冲击研究。虽然热休克研究的特定暴露设置减少了纳入窝仔效应的必要性，但也考虑了这种方法的可能扩展，以解释由窝仔诱导的聚类。
responses on each animal. In this paper, we consider a heatshock study conducted to assess the effects of in vitro exposure of mouse embryos to various levels and durations of heat stress, where the outcomes of interest consist of a series of ordinally classified morphological parameters. Several approaches in the area of developmental toxicity have been suggested for the assessment of multiple binary or continuous developmental outcomes; however, such a strategy has not been well-developed for multiple ordinal outcomes. We present a marginal modeling framework appropriate for correlated ordinal responses which specifies univariate cumulative probabilities for each outcome along with pairwise and higher-order associations. Maximum likelihood and quasi-likelihood approaches for estimating parameters of interest are described, and their relative merits and limitations are discussed in the context of the heatshock study. Although the particular exposure setting of the heatshock studies reduces the need to incorporate litter effects, possible extensions of this methodology to account for the clustering induced by littermates are also considered.
影响因子：
1.9
作者：
LEFKOPOULOU, M;RYAN, L
通讯作者：
RYAN, L
影响因子：
2
作者：
LIPSITZ, SR;KIM, K;ZHAO, LP
通讯作者：
ZHAO, LP
设计发育毒性研究以评估剂量和持续时间的联合效应。
DOI：
10.1111/j.1539-6924.1994.tb00076.x
发表时间：
1994
期刊：
Risk analysis : an official publication of the Society for Risk Analysis
影响因子：
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作者：
Scharfstein,DO;Williams,PL
通讯作者：
Williams,PL