Shared genetic basis for obstructive sleep apnea and adiposity measures
Shared genetic basis for obstructive sleep apnea and adiposity measures
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DOI：
10.1038/sj.ijo.0803803
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发表时间：
2008-05-01
影响因子：
4.9
通讯作者：
Redline, S.
中科院分区：
文献类型：
--
作者：
Patel, S. R.;Larkin, E. K.;Redline, S.
简介：肥胖和阻塞性睡眠呼吸暂停各有一个实质性的遗传基础，通常在个体中共存。这些疾病的遗传基础重叠的程度还没有以前quantitatived.Methods：共有1802个人从310个家庭在克利夫兰家庭研究进行了家庭睡眠研究，以及标准化的评估身体质量指数（BMI）和腰围，臀部和颈部。在713名实验室睡眠研究的参与者中，分析了空腹血液样本中的瘦素，脂联素和瘦素。方差分量模型被用来估计遗传力和遗传correlations.Results：呼吸暂停低通气指数（AHI）的遗传力为0.37 +/- 0.04和0.33 +/- 0.07，分别为家庭和实验室睡眠研究。AHI和拟人肥胖测量值之间的遗传相关性范围为0.57至0.61，表明肥胖可以解释睡眠呼吸暂停中近40%的遗传变异。呼吸暂停严重程度和脂肪因子水平之间的遗传相关性的幅度远小于拟人化措施，范围从0.11到0.46。调整BMI后，没有显着的遗传相关性与呼吸暂停的严重程度，观察到任何其他肥胖measurements.Conclusions：大量的，但不完全重叠的遗传基础之间存在睡眠呼吸暂停和拟人化的肥胖指数，这种重叠占呼吸暂停严重程度的遗传变异的三分之一以上。这些研究结果表明，遗传多态性的存在，重要影响睡眠呼吸暂停的易感性，通过肥胖依赖和非依赖途径。
Introduction: Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified.Methods: A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations.Results: The heritability of the apnea hypopnea index (AHI) was 0.37 +/- 0.04 and 0.33 +/- 0.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any of the other adiposity measures.Conclusions: Substantial but not complete overlap in genetic bases exists between sleep apnea and anthropomorphic indices of adiposity, and this overlap accounts for more than one-third of the genetic variance in apnea severity. These findings suggest that genetic polymorphisms exist that importantly influence sleep apnea susceptibility through both obesity-dependent and -independent pathways.