Performance of liver stiffness measurements by transient elastography in chronic hepatitis
Performance of liver stiffness measurements by transient elastography in chronic hepatitis
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DOI：
10.3748/wjg.v19.i1.49
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发表时间：
2013-01-07
影响因子：
4.3
通讯作者：
Zaramella, Marco
中科院分区：
文献类型：
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作者：
Ferraioli, Giovanna;Tinelli, Carmine;Zaramella, Marco
目的：比较我们的患者人群中获得的瞬时弹性成像（TE）与最近发表的荟萃analysis.METHODS：这是一个单中心的横断面研究中使用的肝硬度测量结果。入选了在我院传染病科门诊进行肝活检的慢性病毒性肝炎连续性患者。使用FibroScan（TM）（Echosens，巴黎，法国）进行TE。作为日间手术，在TE的同一天进行肝活检。根据Metavir评分系统对纤维化进行分期。采用受试者工作特征（ROC）曲线和ROC曲线下面积分析评价TE的诊断性能。6例（2%）患者因TE测量不可靠而被排除。因此，分析了246例（171例男性和75例女性）患者。195例（79.3%）患者患有慢性丙型肝炎，41例（16.7%）患有慢性B型肝炎，10例（4.0%）合并人类免疫缺陷病毒感染。ROC曲线分析表明，所有患者（n = 246）的TE最佳临界值为F ≥ 2 6.9 kPa、F ≥ 3 7.9 kPa、F = 4 9.6 kPa，丙型肝炎患者（n = 195）的TE最佳临界值为F ≥ 2 6.9 kPa、F ≥ 3 7.3 kPa、F = 4 9.3 kPa。仅通过最大化特异性获得的TE的截止值在所有患者（n = 246）中对于F >= 2高达6.9kPa，对于F >= 3高达9.6kPa，对于F = 4高达12.2kPa，对于F >= 2高达7.0kPa，对于F >= 3高达9.3kPa，对于F>= 4高达7.0kPa。12.3 kPa的F = 4的丙型肝炎患者（n = 195）。结论：在这个单中心研究中获得的TE的截止值是可比的，在最近发表的荟萃分析，包括多达40个研究。(C)2013年百世登。All rights reserved.
AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan (TM) (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis.RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F >= 2; 7.9 kPa for F >= 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F >= 2; 7.3 kPa for F >= 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F >= 2; 9.6 kPa for F >= 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F >= 2; 9.3 kPa for F >= 3; 12.3 kPa for F = 4 in patients with hepatitis C ( n = 195).CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. (C) 2013 Baishideng. All rights reserved.