[Cell culture as an experimental system for studying aging processes].
[Cell culture as an experimental system for studying aging processes].
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发表时间：
1983-11
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通讯作者：
M. Steinhardt
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作者：
M. Steinhardt
细胞老化的研究主要局限于两个独立的细胞培养系统的实验和描述性工作。一方面，对体外老化进行了研究，比较了早期和晚期传代的成纤维细胞。另一方面，比较来自不同年龄供体的成纤维细胞（体内老化）。最近，已经取得的结果，指出，一些调查的参数变化类似的两个系统。因此，找到细胞衰老的标准非常重要，不仅可以精确两种细胞培养系统的结果，而且可以得出有关体内生物体衰老的结论。
The investigation of cellular aging has mainly been limited by experimental and descriptive work on two separate cell culture systems. On one hand studies were performed on in vitro aging, comparing fibroblasts in early and late passage. On the other hand, fibroblasts derived from donors of different age were compared (in vivo aging). Recently, results have been achieved, stating that some of the investigated parameters change similarly in both systems. Therefore it is of great importance to find criteria for cellular aging, not only to precise the results in both cell culture systems, but also to be able to draw conclusions concerning aging of the organism in vivo.