PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism
PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism
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DOI：
10.1007/978-3-030-12668-1_13
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Teng, Yong
中科院分区：
文献类型：
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作者：
Lang, Liwei;Chemmalakuzhy, Ron;Teng, Yong
磷酸果糖激酶-1 （PFK-1）是糖酵解的速率决定酶，是调节细胞呼吸过程中葡萄糖氧化的变构酶。糖酵解磷酸果糖激酶血小板（PFKP）是血小板异构体，是细胞代谢的重要介质。考虑到PFKP在癌症发生和转移的许多步骤中起着至关重要的作用，我们综述了PFKP的特异性和复杂性及其在人类疾病，特别是恶性肿瘤中的生物学作用。本文还讨论了PFKP作为诊断标志物或预防或治疗癌症的药物靶点的可能性。
Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.