Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors.
Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors.
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阅读振荡指示：细胞如何实现对振荡转录因子的时间依赖性响应。
DOI：
10.1016/j.ceb.2022.102099
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发表时间：
2022-08
影响因子：
7.5
通讯作者：
Lahav, Galit
中科院分区：
文献类型：
--
作者：
Venkatachalam, Veena;Jambhekar, Ashwini;Lahav, Galit
在撰写关于振荡信号最新发展的观点时，很难忽视过去两年影响我们生活的一个振荡现象：COVID-19大流行，其中病例数的脉动性峰值迫使我们不断调整自己的行为。一些调整发生得很快，例如实施封锁5，而其他调整则需要时间才能显现，例如疫苗开发；但随着每一波电波的出现，新的信息会改变我们对后续电波的反应。生物体中的细胞，就像我们一样，面临着对振荡信号做出反应的挑战——就像我们一样，它们的反应不仅取决于给定信号在某一时刻的水平，还取决于该信号的历史。例如，振荡转录因子（TFs）的水平或10个亚细胞定位随着时间的推移以脉动的方式发生变化，通常显示出目标基因表达的时变模式，其中一些转录速度很快（类似于在COVID病例增加时立即储存洗手液），而另一些转录速度较慢，每脉冲13次（类似于学校关闭，可能在实施上滞后）。除了每次TF脉冲产生的影响外，由早期脉冲触发的表观遗传变化还会影响响应于后期脉冲的转录谱（类似于响应于最初的COVID波的疫苗开发如何改变死亡率）。最后，转录因子本身可能随着时间的推移而发生变化，例如由于翻译后修饰或可用结合伴侣的变化，从而影响其功能（类似于新冠病毒变体的出现如何改变其影响）。20.
When writing a perspective about recent developments in oscillatory signaling, it is hard to 2 ignore one oscillatory phenomenon that has affected our lives over the past two years: the 3 COVID-19 pandemic, in which pulsatile spikes in case counts forced us to continuously adjust 4 our behavior. Some adjustments occurred quickly, such as the implementation of lockdowns, 5 while others took time to manifest, such as vaccine development; but with each wave, new 6 information emerged that altered our response to subsequent waves. 7Cells in an organism, like us, face the challenge of responding to oscillatory signals–and like 8 us, their response depends not only on the level of a given signal at a moment in time, but also 9 on the history of that signal. For instance, oscillating transcription factors (TFs), whose levels or 10 sub-cellular localization change over time in a pulsatile pattern, often show time-varying patterns 11 of target gene expression, with some that are transcribed quickly (akin to the stockpiling of hand 12 sanitizer that occurs as soon as COVID cases rise), and others that turn on more slowly with 13 each pulse (akin to school closures, which may lag in implementation). In addition to effects 14 that occur with each pulse of a TF, epigenetic changes triggered by early pulses can affect 15 transcriptional profiles in response to later pulses (akin to how vaccine development in response 16 to the initial COVID wave altered mortality rates). Finally, transcription factors themselves may 17 undergo changes over time–eg due to post-translational modifications or changes in available 18 binding partners–that affect their function (akin to how the emergence of new COVID variants 19 alters their impact). 20
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影响因子：
9.9
作者：
Harton, Marie D.;Koh, Woo Seuk;Batchelor, Eric
通讯作者：
Batchelor, Eric
影响因子：
9.3
作者：
Sen, Supriya;Cheng, Zhang;Hoffmann, Alexander
通讯作者：
Hoffmann, Alexander
影响因子：
5.9
作者：
Venit, Tomas;Semesta, Khairunnisa;Percipalle, Piergiorgio
通讯作者：
Percipalle, Piergiorgio
影响因子：
30.8
作者：
Lahav, G;Rosenfeld, N;Alon, U
通讯作者：
Alon, U
DOI：
10.1038/nrg3623
发表时间：
2014-03
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Voss TC;Hager GL
通讯作者：
Hager GL