Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats
Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats
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DOI：
10.1097/wnr.0b013e328305b70b
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发表时间：
2008-08-27
期刊：
影响因子：
1.7
通讯作者：
Lima, Carlos
中科院分区：
文献类型：
--
作者：
Iwatsuki, Koichi;Yoshimine, Toshiki;Lima, Carlos
最近的几项研究表明嗅鞘细胞在脊髓损伤中具有潜在的治疗作用。本研究的目的是探讨含有嗅鞘细胞的鼻粘膜移植与不含嗅鞘细胞的鼻呼吸道黏膜移植相比，是否能修复大鼠脊髓损伤。然后将这些移植物移植到部分切除的大鼠脊髓中。与呼吸道黏膜移植大鼠相比，嗅觉黏膜移植大鼠的后肢和关节运动部分恢复。皮质脊髓示踪显示，嗅黏膜移植修复了切断的神经束。因此，嗅觉黏膜在脊髓损伤修复中具有潜在的价值，NeuroReport 19：1249-1252(C)2008 Wolters Kluwer Health竖条Lippincott Williams&Wilkins。
Several recent studies have demonstrated the potential therapeutic role of olfactory ensheathing cells in spinal cord injury. The aim of this study was to elucidate whether grafts of nasal olfactory mucosa containing olfactory ensheathing cells can repair the injured rat spinal cord as compared with the nasal respiratory mucosa containing no olfactory ensheathing cells. These grafts were then transplanted into the partially removed rat spinal cord. Compared with the respiratory mucosa-transplanted rats, the olfactory mucosa-transplanted rats partially recovered the movement of their hindlimbs and joints. Corticospinal tracing indicated that olfactory mucosa transplantation restored the severed tract. Therefore, olfactory mucosa has potential value in the repair of spinal cord injury NeuroReport 19:1249-1252 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.