Acute and Chronic Management of Ocular Disease in Stevens Johnson Syndrome/Toxic Epidermal Necrolysis in the USA.
Acute and Chronic Management of Ocular Disease in Stevens Johnson Syndrome/Toxic Epidermal Necrolysis in the USA.
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DOI：
10.3389/fmed.2021.662897
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发表时间：
2021
影响因子：
3.9
通讯作者：
Saeed HN
中科院分区：
文献类型：
--
作者：
Metcalfe D;Iqbal O;Chodosh J;Bouchard CS;Saeed HN
史蒂文斯约翰逊综合征和中毒性表皮坏死松解症是一种严重的免疫介导的皮肤粘膜疾病。在绝大多数病例中发生眼部受累，严重受累可导致角膜盲。急性期治疗对于减轻慢性疾病的严重程度至关重要。急性治疗的进展，如羊膜移植已显示出显着降低慢性疾病的严重程度。然而，AMT并不是万能的，即使采用积极的急性治疗，严重的慢性眼部疾病仍然会发生。慢性疾病的管理同样重要，因为及时干预可以防止疾病恶化并保护视力。本文简要回顾了SJS/TEN的急性和慢性表现，并讨论了内科和外科治疗策略。
Stevens Johnson syndrome and toxic epidermal necrolysis are on a spectrum of a severe, immune-mediated, mucocutaneous disease. Ocular involvement occurs in the vast majority of cases and severe involvement can lead to corneal blindness. Treatment in the acute phase is imperative in mitigating the severity of chronic disease. Advances in acute treatment such as amniotic membrane transplantation have shown to significantly reduce the severity of chronic disease. However, AMT is not a panacea and severe chronic ocular disease can and does still occur even with aggressive acute treatment. Management of chronic disease is equally critical as timely intervention can prevent worsening of disease and preserve vision. This mini-review describes the acute and chronic findings in SJS/TEN and discusses medical and surgical management strategies.
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