Changes in the concentrations of testosterone and androstenedione in the plasma and testis of the guinea-pig from birth to death.
Changes in the concentrations of testosterone and androstenedione in the plasma and testis of the guinea-pig from birth to death.
复制标题
豚鼠从出生到死亡血浆和睾丸中睾酮和雄烯二酮浓度的变化。
DOI：
--
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
P. Delost
中科院分区：
文献类型：
--
作者：
N. Rigaudière;G. Pélardy;A. Robert;P. Delost
通过气相色谱法测定雄性豚鼠从出生到死亡的间隔（36 个阶段）血浆和睾丸中的睾酮和雄烯二酮浓度。认识到雄激素活性的四个主要时期。新生儿期，从出生到第 16 天，其特点是血浆睾酮浓度在第 2 天和第 3 天出现早熟但短暂的峰值。从第 16 天到第 90 天的青春期可细分为从第 16 天开始的青春期前时期，其特征是血浆和睾丸睾酮浓度突然线性增加，同时睾丸和精囊重量增加，以及从第 50 天开始的青春期后时期 （荷尔蒙青春期）到第 90 天，其特点是雄激素水平高且稳定，同时睾丸和生殖道继续发育。成年期跨越第 3-6 个月和第 24 个月；睾酮和雄烯二酮的血浆和睾丸浓度稳定，但低于青春期观察到的浓度。衰老期发生在第 24 个月至第 28 个月之间，其特点是睾酮分泌下降以及生精小管和副性腺退化。
Testosterone and androstenedione concentrations in the plasma and testis of male guinea-pigs were estimated by gas chromatography at intervals (36 stages) from birth to death. Four main periods of androgenic activity were recognized. The neonatal period, from birth to Day 16, is characterized by a precocious but transient peak in plasma testosterone concentration at Days 2 and 3. The pubertal period from Days 16 to 90 can be subdivided into a prepubertal period starting on Day 16 and marked by a sudden linear increase in plasma and testicular testosterone concentration together with an increase in testicular and seminal vesicle weight, and a postpubertal period, from Day 50 (the time of hormonal puberty) to Day 90, characterized by high and stable androgen levels while testicular and genital tract development continues. Adulthood spans the period between Months 3-6 and Month 24; plasma and testicular concentrations of testosterone and androstenedione are stable but lower than those observed during puberty. The period of senescence occurs between Months 24 and 28 and is marked by a fall in testosterone secretion and involution of the seminiferous tubules and accessory sex glands.