14-3-3 and its possible role in co-ordinating multiple signalling pathways
14-3-3 and its possible role in co-ordinating multiple signalling pathways
复制标题
DOI：
10.1016/0962-8924(96)10029-5
复制
发表时间：
1996-09-01
影响因子：
19
通讯作者：
Aitken, A
中科院分区：
文献类型：
--
作者：
Aitken, A
14-3-3家族的成员是同源和异源二聚体蛋白质，介导许多生物活性的不同组分之间的相互作用。这些蛋白质的作用已经不清楚了一段时间，但他们现在正在获得接受作为一种新型的伴侣蛋白，调节信号转导通路的组件之间的相互作用。最近的研究表明，结合伴侣的磷酸化以及14-3-3蛋白本身的磷酸化在调节这些相互作用中很重要。通过对Raf中主要磷酸化位点的分析，发现了一个新的序列基序R（S）X（1，2）S（P）X（P），它可能代表了14-3-3结合蛋白的保守相互作用位点。
Members of the 14-3-3 family are homo- and heterodimeric proteins mediating interaction between diverse components of many biological activities. The role of these proteins has been unclear for some time, but they are now gaining acceptance as a novel type of chaperone protein that modulates interactions between components of signal-transduction pathways. It is becoming apparent from recent studies that phosphorylation of the binding partner and possibly also the 14-3-3 proteins themselves is important in regulating these interactions. Analysis of the major sites of phosphorylation in Raf has led to the identification of a novel sequence motif, R(S)X(1,2)S(P)X(P), that may represent a conserved interaction site for 14-3-3-binding proteins.