Key role of coupling, delay, and noise in resting brain fluctuations
Key role of coupling, delay, and noise in resting brain fluctuations
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DOI：
10.1073/pnas.0901831106
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发表时间：
2009-06-23
影响因子：
11.1
通讯作者：
Koetter, Rolf
中科院分区：
文献类型：
--
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
越来越多的神经影像学研究表明，在没有明确任务的情况下，大脑会表现出时间上连贯的活动。这种所谓的“静息态”活动，或者更明确地说，默认模式网络，与人的白日梦、自由联想、意识流或内心演练有关，但在麻醉状态下以及猴子身上也发现了类似的模式。默认模式网络中的时空活动模式既复杂又具有一致性，这就提出了一个问题：它们是一种有趣的认知结构的表现，还是内在网络约束的结果。在数值模拟中，我们使用38个受噪声驱动的（威尔逊 - 考恩）振荡器研究了一个简化皮质网络的动力学，这些振荡器在孤立状态下刚好处于其振荡阈值以下。基于灵长类皮质 - 皮质通路的长度和强度的时间延迟耦合导致了两组40赫兹振荡器的出现。这两组振荡器表现出在……处反相关的同步。
A growing body of neuroimaging research has documented that, in the absence of an explicit task, the brain shows temporally coherent activity. This so-called "resting state'' activity or, more explicitly, the default-mode network, has been associated with daydreaming, free association, stream of consciousness, or inner rehearsal in humans, but similar patterns have also been found under anesthesia and in monkeys. Spatiotemporal activity patterns in the default-mode network are both complex and consistent, which raises the question whether they are the expression of an interesting cognitive architecture or the consequence of intrinsic network constraints. In numerical simulation, we studied the dynamics of a simplified cortical network using 38 noise-driven (Wilson-Cowan) oscillators, which in isolation remain just below their oscillatory threshold. Time delay coupling based on lengths and strengths of primate corticocortical pathways leads to the emergence of 2 sets of 40-Hz oscillators. The sets showed synchronization that was anticorrelated at