Role of monocytes and macrophages in angiogenesis.
Role of monocytes and macrophages in angiogenesis.
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DOI：
10.1007/3-7643-7311-3_9
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Leni Moldovan;N. Moldovan
中科院分区：
文献类型：
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作者：
Leni Moldovan;N. Moldovan
胚胎中新血管的形成是通过血管发生发生的，血管发生包括源自细胞前体血管母细胞的血管结构的发育[1]。随后，微血管床的扩张或再生依赖于血管生成，即新毛细血管的形成，被认为是通过发芽机制源自预先存在的内皮细胞（EC）[2]。在这两种情况下，新血管的形成都是基于单一细胞类型的特性[3]。然而，该模型的简单性受到新微血管诞生现场普遍存在的其他细胞类型的挑战。例如，CD45（成体生物体中的一种白细胞标记物）呈阳性的造血干细胞始终存在于小鼠胚胎毛细血管的前进前端[4]。类似地，单核细胞/巨噬细胞 (MC/Mph) 与成年动物中各种血管生成环境中毛细血管的发育有关，如下所述。迄今为止，MC/Mph 的存在主要是从调节因子分泌的角度来考虑的。然而，新数据以及对旧数据的重新检查表明，MC/Mph 也可能在机械和结构上促进毛细血管的形成。
Formation of new blood vessels in the embryo takes place through vasculogenesis, which consists of the development of vascular structures originating from cellular precursors, the angioblasts [1]. Later on, the expansion or regeneration of microvascular beds relies on angiogenesis, ie, the formation of new capillaries thought to derive from pre-existent endothelial cells (EC) by the mechanism of sprouting [2]. In both cases, the formation of new blood vessels proceeds based on the properties of a single cell type [3]. However, the simplicity of this model is challenged by the ubiquitous presence of other cell types at the scene of birth of new microvessels. For example, hematopoietic stem cells positive for CD45 (a leukocyte marker in adult organisms) are consistently found at the advancing front of capillaries in the mouse embryos [4]. Similarly, monocytes/macrophages (MC/Mph) are associated with the developing capillaries in various angiogenic settings in adult animals, as described below. The presence of MC/Mph is considered thus far mostly from the point of view of the secretion of regulatory factors. Nevertheless, new data as well as the re-examination of older data suggests that MC/Mph may also contribute both mechanistically and structurally to the formation of capillaries.