Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer
Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer
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DOI：
10.1002/path.1051
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发表时间：
2002-03-01
影响因子：
7.3
通讯作者：
Mellon, JK
中科院分区：
文献类型：
--
作者：
Davies, BR;O'Donnell, M;Mellon, JK
钙结合蛋白S100A4在啮齿类动物乳腺癌模型中诱导转移表型，其表达与人乳腺癌生存率降低密切相关。应用免疫细胞化学方法研究了S100A4在正常膀胱和101例膀胱肿瘤中的表达。在28%的肿瘤中发现S100A4的中度或强表达，而其余肿瘤和正常尿路上皮细胞未染色或显示弱染色。S100A4染色在浸润性膀胱肿瘤中比在非浸润性肿瘤中更频繁地观察到（p < 0.05）。在浸润性肿瘤中，S100A4染色通常在浸润区域和单个浸润细胞中最强。S100A4表达与转移（p=0.0003）和生存率降低（p < 0.0001）之间存在统计学显著相关性。它的结论是，S100A4的表达可能发挥，在膀胱癌中的重要作用，并可能确定一个亚组的患者转移的风险增加，应考虑辅助全身治疗。版权所有（C）2002约翰威利父子有限公司
The calcium-binding protein S100A4 induces the metastatic phenotype in rodent models of breast cancer and its expression correlates strongly with reduced survival in human breast cancer. The expression of S100A4 in normal bladders and 101 bladder tumours has been studied using immunocytochemistry. Moderate or strong expression of S100A4 was found in 28% of the tumours, whilst the remaining tumours and normal urothelium either failed to stain or showed weak staining. S100A4 staining was more frequently observed in invasive bladder tumours than in non-invasive tumours (p < 0.05). In invasive tumours, S100A4 staining was usually, strongest in invasive regions and single infiltrating cells. Statistically significant associations were found between S100A4 expression and metastasis (p=0.0003) and reduced survival (p < 0.0001). It is concluded that S100A4 expression may play, an important role in bladder cancer and may identify a subgroup of patients at increased risk of metastasis who should be considered for adjuvant systemic therapy. Copyright (C) 2002 John Wiley Sons, Ltd.