Crossover comparison of ferumoxytol and gadobenate dimeglumine for abdominal MR-angiography at 3.0 tesla: Effects of contrast bolus length and flip angle.
Crossover comparison of ferumoxytol and gadobenate dimeglumine for abdominal MR-angiography at 3.0 tesla: Effects of contrast bolus length and flip angle.
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DOI：
10.1002/jmri.25513
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Reeder SB
中科院分区：
文献类型：
--
作者：
Schubert T;Motosugi U;Kinner S;Colgan TJ;Sharma SD;Hetzel S;Wells S;Campo CA;Reeder SB
Ferumoxytol has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA. Twelve healthy volunteers (6 women / 6 men, mean age 44.3y) were recruited for this study. Scanning was performed on a clinical 3T MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by ferumoxytol (FE)-enhanced MRA one month later. Volunteers were randomly assigned to a diluted (n=6) or undiluted (n=6) dose of GD (0.1 mmol/kg), and to FE doses of 4mg/kg (n=6) or 2mg/kg (n=6). First pass and steady-state MRA were performed for GD- and FE-enhanced MRA. Flip-angle optimization was performed after ferumoxytol administration. Quantitative analysis included relative contrast-to-noise ratio (relCNR) measurements for all acquisitions. First pass GD- and FE-enhanced MRA images were evaluated qualitatively. RelCNR was significantly higher with undiluted GD (31.8, 95%CI 27.7-35.9) compared to diluted GD (16.2 (12.2-20.3), p=0.001) and both 4mg/kg FE (12.5 (8.5-16.4), p<0.001) and 2mg/kg FE (9.1 (5.1-13.2), p<0.001) during first pass. Relative CNR did not decrease with ferumoxytol 5 min post injection compared to GD. Flip-angle analysis revealed relative CNR-peaks at 30° for FE 4mg/kg and at 20° for FE 2mg/kg. Diluted GD (p=0.013) and FE 4mg/kg (p=0.01) revealed significantly higher image quality scores compared to undiluted GD during first pass. This study shows an equivalent image quality of FE and GD for first pass MRA even though GD showed significantly higher relative CNR.
