Reliability of macaque frontal eye field neurons signaling saccade targets during visual search
Reliability of macaque frontal eye field neurons signaling saccade targets during visual search
复制标题
DOI：
10.1523/jneurosci.21-02-00713.2001
复制
发表时间：
2001-01-15
影响因子：
5.3
通讯作者：
Schall, JD
中科院分区：
文献类型：
--
作者：
Bichot, NP;Thompson, KG;Schall, JD
虽然许多研究已经探索了视觉注意和选择的神经相关性，但很少有人研究神经元代表相关信息的可靠性。我们监测活动的额叶眼场（FEF）的猴子训练，使眼跳的颜色和形状的结合定义的目标或颜色差异定义的目标。连接搜索的难度通过改变干扰物的数量来操纵，特征搜索的难度通过改变目标和干扰物之间的颜色相似性来操纵。单个神经元在正确试验中发出目标位置信号的可靠性使用赢家通吃架构内的神经元-反神经元方法来确定。平均而言，在最简单的搜索中，对单个神经元的活动进行大约7次试验就足以匹配近乎完美的行为表现，而在最困难的搜索中，进行类似的14次试验就足够了。我们还确定了在一次试验中需要评估多少单独记录的神经元才能与行为表现相匹配。结果在定量上与单神经元分析的结果相似。我们还发现，FEF中的信号可靠性不随任务需求而变化，并且总体而言，当仅组合六个试验或神经元时，搜索任务的行为准确性近似。此外，无论是结合试验还是神经元，目标辨别时间的增加对应于视觉搜索难度水平上平均眼跳潜伏期的增加。最后，在FEF的尖峰计数的方差增加的函数的平均尖峰计数，这种关系的参数并没有改变与注意选择。
Although many studies have explored the neural correlates of visual attention and selection, few have examined the reliability with which neurons represent relevant information. We monitored activity in the frontal eye field (FEF) of monkeys trained to make a saccade to a target defined by the conjunction of color and shape or to a target defined by color differences. The difficulty of conjunction search was manipulated by varying the number of distractors, and the difficulty of feature search was manipulated by varying the similarity in color between target and distractors. The reliability of individual neurons in signaling the target location in correct trials was determined using a neuron-anti-neuron approach within a winner-take-all architecture. On average, approximately seven trials of the activity of single neurons were sufficient to match near-perfect behavioral performance in the easiest search, and similar to 14 trials were sufficient in the most difficult search. We also determined how many neurons recorded separately need to be evaluated within a trial to match behavioral performance. Results were quantitatively similar to those of the single neuron analysis. We also found that signal reliability in the FEF did not change with task demands, and overall, behavioral accuracy across the search tasks was approximated when only six trials or neurons were combined. Furthermore, whether combining trials or neurons, the increase in time of target discrimination corresponded to the increase in mean saccade latency across visual search difficulty levels. Finally, the variance of spike counts in the FEF increased as a function of the mean spike count, and the parameters of this relationship did not change with attentional selection.