Vascularization is delayed in long nerve constructs compared with nerve grafts.
Vascularization is delayed in long nerve constructs compared with nerve grafts.
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DOI：
10.1002/mus.25173
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发表时间：
2016-08
期刊：
影响因子：
3.4
通讯作者：
Wood MD
中科院分区：
文献类型：
--
作者：
Farber SJ;Hoben GM;Hunter DA;Yan Y;Johnson PJ;Mackinnon SE;Wood MD
Nerve regeneration across nerve constructs, such as acellular nerve allografts (ANAs), is inferior to nerve auto/isografts especially in the case of long defect lengths. Vascularization may contribute to poor regeneration. The time course of vascular perfusion within long grafts and constructs was tracked to determine vascularization. Male Lewis rat sciatic nerves were transected and repaired with 6 cm isografts or ANAs. At variable days following grafting, animals were perfused with Evans Blue albumin, and grafts were evaluated for vascular perfusion by a blinded observer. Vascularization at the mid-graft was re-established within 3–4 days in 6 cm isografts, while it was established after 10 days in 6 cm ANAs. Vascular perfusion is reestablished over a shorter time course in long isografts when compared to long ANAs. The differences in vascularization of long ANAs compared to auto/isografts suggest regenerative outcomes across ANAs could be impacted by vascularization rates.
